| Literature DB >> 17064245 |
Domenic A Sica1, Thomas E Lohmeier.
Abstract
This article reviews the history and current status of an innovative nonpharmacological approach for the treatment of resistant hypertension - chronic electrical activation of the afferent limb of the carotid baroreflex. Recent studies in both normotensive and hypertensive canine models have unambiguously demonstrated sustained and clinically relevant reductions in arterial pressure and sympathetic activity in the course of prolonged baroreflex activation. Clinical trials designed to evaluate the efficacy and safety of this therapy in patients with resistant hypertension are now underway in both Europe and the USA.Entities:
Mesh:
Year: 2006 PMID: 17064245 DOI: 10.1586/17434440.3.5.595
Source DB: PubMed Journal: Expert Rev Med Devices ISSN: 1743-4440 Impact factor: 3.166