| Literature DB >> 17062879 |
Massimo Santoro1, Rosa Marina Melillo, Alfredo Fusco.
Abstract
Papillary thyroid carcinoma (PTC) is frequently associated with RET gene rearrangements that generate the so-called RET/PTC oncogenes. In this review, we examine the data about the mechanisms of thyroid cell transformation, activation of downstream signal transduction pathways and modulation of gene expression induced by RET/PTC. These findings have advanced our understanding of the processes underlying PTC formation and provide the basis for novel therapeutic approaches to this disease.Entities:
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Year: 2006 PMID： 17062879 DOI： 10.1530/eje.1.02289
Source DB: PubMed Journal: Eur J Endocrinol ISSN： 0804-4643 Impact factor: 6.664