OBJECTIVE: To evaluate the possible relationship of hypertension and diabetes with the ABO, Rhesus, and Duffy blood groups, which are known markers of African ancestry. DESIGN: Population-based study. SETTING AND PARTICIPANTS: A random sample of 1253 Barbados residents, > or = 40 years of age. MAIN OUTCOME MEASURES: Hypertension was defined as a systolic blood pressure >140 mm Hg or a diastolic blood pressure >90 mm Hg or use of antihypertensive treatment; type 2 diabetes was defined as a glycosylated hemoglobin level >10% and/or a history of treatment in those >30 years of age. RESULTS: In logistic regression analyses, elevated diastolic blood pressure was positively associated with years of age (odds ratio [OR] 1.03, 95% confidence interval CI 1.02-1.05), the Rhesus D+ antigen (OR 2.68, 95% CI 1.21-5.97) and body mass index (OR 1.53, 95% CI 1.19-1.96), but negatively associated with the ABO blood group A allele (OR 0.68, 95% CI .48-.97). A separate logistic regression model indicated that the likelihood of diabetes increased with years of age (OR 1.03, 95% CI 1.01-1.04), hypertension (OR 1.56, 95% CI 1.10-2.20), body mass index (OR 1.68, 95% CI 1.29-2.20), and waist-hip ratio (OR 1.36, 95% CI 1.05-1.75), but decreased with presence of the Rhesus C+ antigen (OR .66, 95% CI .44-.97). CONCLUSIONS: The associations of diabetes and hypertension to these blood groups support possible genetic influences on both conditions in this and similar African-origin populations; however, further investigations in other settings are necessary to more fully elucidate these findings.
OBJECTIVE: To evaluate the possible relationship of hypertension and diabetes with the ABO, Rhesus, and Duffy blood groups, which are known markers of African ancestry. DESIGN: Population-based study. SETTING AND PARTICIPANTS: A random sample of 1253 Barbados residents, > or = 40 years of age. MAIN OUTCOME MEASURES: Hypertension was defined as a systolic blood pressure >140 mm Hg or a diastolic blood pressure >90 mm Hg or use of antihypertensive treatment; type 2 diabetes was defined as a glycosylated hemoglobin level >10% and/or a history of treatment in those >30 years of age. RESULTS: In logistic regression analyses, elevated diastolic blood pressure was positively associated with years of age (odds ratio [OR] 1.03, 95% confidence interval CI 1.02-1.05), the Rhesus D+ antigen (OR 2.68, 95% CI 1.21-5.97) and body mass index (OR 1.53, 95% CI 1.19-1.96), but negatively associated with the ABO blood group A allele (OR 0.68, 95% CI .48-.97). A separate logistic regression model indicated that the likelihood of diabetes increased with years of age (OR 1.03, 95% CI 1.01-1.04), hypertension (OR 1.56, 95% CI 1.10-2.20), body mass index (OR 1.68, 95% CI 1.29-2.20), and waist-hip ratio (OR 1.36, 95% CI 1.05-1.75), but decreased with presence of the Rhesus C+ antigen (OR .66, 95% CI .44-.97). CONCLUSIONS: The associations of diabetes and hypertension to these blood groups support possible genetic influences on both conditions in this and similar African-origin populations; however, further investigations in other settings are necessary to more fully elucidate these findings.
Authors: Lu Qi; Marilyn C Cornelis; Peter Kraft; Majken Jensen; Rob M van Dam; Qi Sun; Cynthia J Girman; Cathy C Laurie; Daniel B Mirel; David J Hunter; Eric Rimm; Frank B Hu Journal: Hum Mol Genet Date: 2010-02-10 Impact factor: 6.150
Authors: Britney E Graham; Christian Darabos; Minjun Huang; Louis J Muglia; Jason H Moore; Scott M Williams Journal: Genet Epidemiol Date: 2017-09-25 Impact factor: 2.135