| Literature DB >> 17060582 |
G Chana1, I P Everall, L Crews, D Langford, A Adame, I Grant, M Cherner, D Lazzaretto, R Heaton, R Ellis, E Masliah.
Abstract
The cellular basis for cognitive deficits in HIV+ patients with and without a history of methamphetamine (METH) use is unclear. We found that HIV+ METH users had more severe loss of interneurons that was associated with cognitive impairment. Compared with other markers, loss of calbindin and parvalbumin interneurons in the frontal cortex was the most significant correlate to memory deficits, suggesting a role in neurobehavioral alterations of HIV+ METH users.Entities:
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Year: 2006 PMID： 17060582 DOI： 10.1212/01.wnl.0000240066.02404.e6
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910