| Literature DB >> 17060575 |
M Capasso1, A Di Muzio, M Comar, I Robuffo, A Gambi, S Crovella, E Pizzigallo, C Campello, A Uncini.
Abstract
In two patients with chronic hepatitis B and myopathy, muscle biopsy showed necrosis and scarce inflammatory infiltrates. CD8+ cells surrounded some non-necrotic fibers. Hepatitis B virus (HBV) DNA and antigens were found inside intact muscle fibers. Major histocompatibility complex class I antigens were coexpressed with viral antigens. In one patient, symptoms improved during antiviral therapy. HBV can infect muscle fibers and an immune-mediated response to viral antigens may cause muscle injury.Entities:
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Year: 2006 PMID： 17060575 DOI： 10.1212/01.wnl.0000240078.47020.5e
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910