BACKGROUND: A family history of stroke is an independent risk factor for stroke. OBJECTIVE: To assess whether severity of neurologic deficit after stroke is associated with a family history of stroke. METHODS: The Ischemic Stroke Genetics Study, a five-center study of first-ever symptomatic ischemic stroke, assessed case subjects prospectively for a family history of stroke-affected first-degree relatives. Certified adjudicators used the NIH Stroke Scale (NIHSS) to determine the severity of neurologic deficit. RESULTS: A total of 505 case subjects were enrolled (median age, 65 years; 55% male), with 81% enrolled within 1 week of onset of symptoms. A sibling history of stroke was associated with more severe stroke. The odds of an NIHSS score of 5 or higher were 2.0 times greater for cases with a sibling history of stroke compared with cases with no sibling history (95% CI, 1.0 to 3.9). An association of family history of stroke in parents or children with stroke severity was not detected. CONCLUSIONS: A sibling history of stroke increased the likelihood of a more severe stroke in the case subjects, independent of age, sex, and other potential confounding factors. Other family history characteristics were not associated with stroke severity.
BACKGROUND: A family history of stroke is an independent risk factor for stroke. OBJECTIVE: To assess whether severity of neurologic deficit after stroke is associated with a family history of stroke. METHODS: The Ischemic Stroke Genetics Study, a five-center study of first-ever symptomatic ischemic stroke, assessed case subjects prospectively for a family history of stroke-affected first-degree relatives. Certified adjudicators used the NIH Stroke Scale (NIHSS) to determine the severity of neurologic deficit. RESULTS: A total of 505 case subjects were enrolled (median age, 65 years; 55% male), with 81% enrolled within 1 week of onset of symptoms. A sibling history of stroke was associated with more severe stroke. The odds of an NIHSS score of 5 or higher were 2.0 times greater for cases with a sibling history of stroke compared with cases with no sibling history (95% CI, 1.0 to 3.9). An association of family history of stroke in parents or children with stroke severity was not detected. CONCLUSIONS: A sibling history of stroke increased the likelihood of a more severe stroke in the case subjects, independent of age, sex, and other potential confounding factors. Other family history characteristics were not associated with stroke severity.
Authors: M H Lev; A Z Segal; J Farkas; S T Hossain; C Putman; G J Hunter; R Budzik; G J Harris; F S Buonanno; M A Ezzeddine; Y Chang; W J Koroshetz; R G Gonzalez; L H Schwamm Journal: Stroke Date: 2001-09 Impact factor: 7.914
Authors: Joanne M Murabito; Byung-Ho Nam; Ralph B D'Agostino; Donald M Lloyd-Jones; Christopher J O'Donnell; Peter W F Wilson Journal: Ann Intern Med Date: 2004-03-16 Impact factor: 25.391
Authors: James F Meschia; Thomas G Brott; Robert D Brown; Richard J P Crook; Michael Frankel; John Hardy; José G Merino; Stephen S Rich; Scott Silliman; Bradford Burke Worrall Journal: BMC Neurol Date: 2003-07-08 Impact factor: 2.474
Authors: N Stroud; T M L Mazwi; L D Case; R D Brown; T G Brott; B B Worrall; J F Meschia Journal: J Neurol Neurosurg Psychiatry Date: 2009-07-14 Impact factor: 10.154
Authors: Dawn M Aycock; Kenya D Kirkendoll; Kisha C Coleman; Patricia C Clark; Karen C Albright; Anne W Alexandrov Journal: J Cardiovasc Nurs Date: 2015 Mar-Apr Impact factor: 2.083