Literature DB >> 17060526

Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients.

Caroline A Obert1, Martha L Miller, Jeremy Montgomery, Thomas Adamkiewicz, Elaine I Tuomanen.   

Abstract

Sickle cell disease (SCD) is a risk factor for fatal pneumococcal infection. Nonsusceptibilty to quinupristin-dalfopristin (Q-D) was absent from 105 non-SCD-associated pneumococcal isolates but was present in 33/148 (22%) SCD-associated isolates. One-third of the isolates harbored a known resistance mechanism. Q-D is not optimal for use for the treatment of pneumococcal infection in SCD patients.

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Year:  2006        PMID： 17060526      PMCID： PMC1797651          DOI： 10.1128/AAC.01016-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

1.  Quinupristin-dalfopristin resistance in Streptococcus pneumoniae: novel L22 ribosomal protein mutation in two clinical isolates from the SENTRY antimicrobial surveillance program.

Authors:  Ronald N Jones; David J Farrell; Ian Morrissey
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

2.  The streptogramin antibiotics: update on their mechanism of action.

Authors:  D Beyer; K Pepper
Journal:  Expert Opin Investig Drugs       Date:  1998-04       Impact factor: 6.206

3.  Sequence of a staphylococcal plasmid gene, vga, encoding a putative ATP-binding protein involved in resistance to virginiamycin A-like antibiotics.

Authors:  J Allignet; V Loncle; N el Sohl
Journal:  Gene       Date:  1992-08-01       Impact factor: 3.688

4.  Characterization of a staphylococcal plasmid related to pUB110 and carrying two novel genes, vatC and vgbB, encoding resistance to streptogramins A and B and similar antibiotics.

Authors:  J Allignet; N Liassine; N el Solh
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191

5.  Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.

Authors:  H Tettelin; K E Nelson; I T Paulsen; J A Eisen; T D Read; S Peterson; J Heidelberg; R T DeBoy; D H Haft; R J Dodson; A S Durkin; M Gwinn; J F Kolonay; W C Nelson; J D Peterson; L A Umayam; O White; S L Salzberg; M R Lewis; D Radune; E Holtzapple; H Khouri; A M Wolf; T R Utterback; C L Hansen; L A McDonald; T V Feldblyum; S Angiuoli; T Dickinson; E K Hickey; I E Holt; B J Loftus; F Yang; H O Smith; J C Venter; B A Dougherty; D A Morrison; S K Hollingshead; C M Fraser
Journal:  Science       Date:  2001-07-20       Impact factor: 47.728

6.  Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease.

Authors:  Caroline Obert; Jack Sublett; Deepak Kaushal; Ernesto Hinojosa; Theresa Barton; Elaine I Tuomanen; Carlos J Orihuela
Journal:  Infect Immun       Date:  2006-08       Impact factor: 3.441

7.  Invasive pneumococcal infections in children with sickle cell disease in the era of penicillin prophylaxis, antibiotic resistance, and 23-valent pneumococcal polysaccharide vaccination.

Authors:  Thomas V Adamkiewicz; Sharada Sarnaik; George R Buchanan; Rathi V Iyer; Scott T Miller; Charles H Pegelow; Zora R Rogers; Elliott Vichinsky; John Elliott; Richard R Facklam; Katherine L O'Brien; Benjamin Schwartz; Chris A Van Beneden; Michael J Cannon; James R Eckman; Harry Keyserling; Kevin Sullivan; Wing-Yen Wong; Winfred C Wang
Journal:  J Pediatr       Date:  2003-10       Impact factor: 4.406

8.  Nontherapeutic use of antimicrobial agents in animal agriculture: implications for pediatrics.

Authors:  Katherine M Shea
Journal:  Pediatrics       Date:  2004-09       Impact factor: 7.124

9.  Sequence of a staphylococcal gene, vat, encoding an acetyltransferase inactivating the A-type compounds of virginiamycin-like antibiotics.

Authors:  J Allignet; V Loncle; C Simenel; M Delepierre; N el Solh
Journal:  Gene       Date:  1993-08-16       Impact factor: 3.688

10.  Tolerance to vancomycin in pneumococci: detection with a molecular marker and assessment of clinical impact.

Authors:  Carina A Rodriguez; Robyn Atkinson; Wally Bitar; Cynthia G Whitney; Kathryn M Edwards; Lauren Mitchell; Juan Li; Jack Sublett; Chin-Shang Li; Tiebin Liu; P Joan Chesney; Elaine I Tuomanen
Journal:  J Infect Dis       Date:  2004-09-09       Impact factor: 5.226
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