Literature DB >> 17060521

Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance.

Nicolas Papon1, Thierry Noël, Martine Florent, Stéphanie Gibot-Leclerc, Dorothée Jean, Christiane Chastin, Jean Villard, Florence Chapeland-Leclerc.   

Abstract

Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil, whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.

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Year:  2006        PMID： 17060521      PMCID： PMC1797687          DOI： 10.1128/AAC.00824-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

Review 1.  Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions.

Authors:  A Vermes; H J Guchelaar; J Dankert
Journal:  J Antimicrob Chemother       Date:  2000-08       Impact factor: 5.790

2.  Repeated use of GAL1 for gene disruption in Candida albicans.

Authors:  J A Gorman; W Chan; J W Gorman
Journal:  Genetics       Date:  1991-09       Impact factor: 4.562

3.  Pitfalls of the synthetic lethality screen in Saccharomyces cerevisiae: an improved design.

Authors:  Amnon Koren; Shay Ben-Aroya; Rivka Steinlauf; Martin Kupiec
Journal:  Curr Genet       Date:  2003-02-05       Impact factor: 3.886

4.  Inactivation of the FCY2 gene encoding purine-cytosine permease promotes cross-resistance to flucytosine and fluconazole in Candida lusitaniae.

Authors:  Florence Chapeland-Leclerc; Julien Bouchoux; Abdelhak Goumar; Christiane Chastin; Jean Villard; Thierry Noël
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

5.  A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains.

Authors:  E Alani; L Cao; N Kleckner
Journal:  Genetics       Date:  1987-08       Impact factor: 4.562

6.  Various cytosine/adenine permease homologues are involved in the toxicity of 5-fluorocytosine in Saccharomyces cerevisiae.

Authors:  John P Paluszynski; Roland Klassen; Matthias Rohe; Friedhelm Meinhardt
Journal:  Yeast       Date:  2006-07-15       Impact factor: 3.239

7.  Substrate connectivity effects in the transition state for cytidine deaminase.

Authors:  D Carlow; R Wolfenden
Journal:  Biochemistry       Date:  1998-08-25       Impact factor: 3.162

Review 8.  Current and emerging azole antifungal agents.

Authors:  D J Sheehan; C A Hitchcock; C M Sibley
Journal:  Clin Microbiol Rev       Date:  1999-01       Impact factor: 26.132

9.  Development of an integrative transformation system for the opportunistic pathogenic yeast Candida lusitaniae using URA3 as a selection marker.

Authors:  Fabienne François; Florence Chapeland-Leclerc; Jean Villard; Thierry Noël
Journal:  Yeast       Date:  2004-01-30       Impact factor: 3.239

10.  Flucytosine-fluconazole cross-resistance in purine-cytosine permease-deficient Candida lusitaniae clinical isolates: indirect evidence of a fluconazole uptake transporter.

Authors:  Thierry Noël; Fabienne François; Patrick Paumard; Christiane Chastin; Daniel Brèthes; Jean Villard
Journal:  Antimicrob Agents Chemother       Date:  2003-04       Impact factor: 5.191
  10 in total
  30 in total

1.  Acquired Multidrug Antifungal Resistance in Candida lusitaniae during Therapy.

Authors:  Sandra A Asner; Stefano Giulieri; Manuel Diezi; Oscar Marchetti; Dominique Sanglard
Journal:  Antimicrob Agents Chemother       Date:  2015-10-05       Impact factor: 5.191

2.  Deletion of the uracil permease gene confers cross-resistance to 5-fluorouracil and azoles in Candida lusitaniae and highlights antagonistic interaction between fluorinated nucleotides and fluconazole.

Authors:  Frédéric Gabriel; Ayman Sabra; Sofiane El-Kirat-Chatel; Sophie Pujol; Valérie Fitton-Ouhabi; Daniel Brèthes; Karine Dementhon; Isabelle Accoceberry; Thierry Noël
Journal:  Antimicrob Agents Chemother       Date:  2014-05-27       Impact factor: 5.191

3.  A TRP5/5-fluoroanthranilic acid counter-selection system for gene disruption in Candida guilliermondii.

Authors:  Emilien Foureau; Marc Clastre; Yoann Millerioux; Andrew J Simkin; Lucie Cornet; Christelle Dutilleul; Sébastien Besseau; Emeline Marais; Céline Melin; Jérôme Guillard; Joël Crèche; Nathalie Giglioli-Guivarc'h; Vincent Courdavault; Nicolas Papon
Journal:  Curr Genet       Date:  2012-05-23       Impact factor: 3.886

4.  Molecular mechanisms of resistance to 5-fluorocytosine in laboratory mutants of Candida glabrata.

Authors:  Patrick Vandeputte; Laurent Pineau; Gérald Larcher; Thierry Noel; Daniel Brèthes; Dominique Chabasse; Jean-Philippe Bouchara
Journal:  Mycopathologia       Date:  2010-07-09       Impact factor: 2.574

5.  Loss of heterozygosity of FCY2 leading to the development of flucytosine resistance in Candida tropicalis.

Authors:  Yen-Ning Chen; Hsiu-Jung Lo; Chia-Chen Wu; Hui-Ching Ko; Te-Pin Chang; Yun-Liang Yang
Journal:  Antimicrob Agents Chemother       Date:  2011-03-21       Impact factor: 5.191

6.  Insight into the role of HOG pathway components Ssk2p, Pbs2p, and Hog1p in the opportunistic yeast Candida lusitaniae.

Authors:  Stéphanie Boisnard; Gwenaël Ruprich-Robert; Martine Florent; Bruno Da Silva; Florence Chapeland-Leclerc; Nicolas Papon
Journal:  Eukaryot Cell       Date:  2008-10-24

7.  A Ser29Leu substitution in the cytosine deaminase Fca1p is responsible for clade-specific flucytosine resistance in Candida dubliniensis.

Authors:  Brenda A McManus; Gary P Moran; Judy A Higgins; Derek J Sullivan; David C Coleman
Journal:  Antimicrob Agents Chemother       Date:  2009-08-24       Impact factor: 5.191

8.  Contributions of the response regulators Ssk1p and Skn7p in the pseudohyphal development, stress adaptation, and drug sensitivity of the opportunistic yeast Candida lusitaniae.

Authors:  Gwenaël Ruprich-Robert; Florence Chapeland-Leclerc; Stéphanie Boisnard; Martine Florent; Gaël Bories; Nicolas Papon
Journal:  Eukaryot Cell       Date:  2008-04-11

9.  Differential involvement of histidine kinase receptors in pseudohyphal development, stress adaptation, and drug sensitivity of the opportunistic yeast Candida lusitaniae.

Authors:  Florence Chapeland-Leclerc; Paméla Paccallet; Gwenaël Ruprich-Robert; David Reboutier; Christiane Chastin; Nicolas Papon
Journal:  Eukaryot Cell       Date:  2007-07-27

10.  Mechanistic Basis of pH-Dependent 5-Flucytosine Resistance in Aspergillus fumigatus.

Authors:  Fabio Gsaller; Takanori Furukawa; Paul D Carr; Bharat Rash; Christoph Jöchl; Margherita Bertuzzi; Elaine M Bignell; Michael J Bromley
Journal:  Antimicrob Agents Chemother       Date:  2018-05-25       Impact factor: 5.191
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