OBJECTIVE: Serum S-100B protein is an established biochemical marker of traumatic brain injury. At the same time, the question of extra-cranial S-100B release has been raised. This study evaluates the post-traumatic and post-operative release kinetics of S-100B in 45 trauma victims without head injury. METHOD: Serum S-100B protein was measured on admission and every 24 hours for 4 consecutive days. RESULTS: Initial S-100B was slightly increased (median: 0.54 microg L-1) and correlated with the severity of extra-cranial trauma (p = 0.0004, Mann-Whitney test). Both severely (abdominal or chest trauma with or without bone fractures) and mildly (long bone fractures) injured showed a rapid decline of S-100B (< 0.2 microg L-1) around 72 hours post-trauma. Extra-cranial surgery caused a secondary increase of S-100B, especially in the mildly injured group (p = 0.004, Wilcoxon signed rank test). CONCLUSIONS: Extra-cranial injury results in a mild elevation of serum S-100B protein that declines rapidly (1-3 days after injury).
OBJECTIVE: Serum S-100B protein is an established biochemical marker of traumatic brain injury. At the same time, the question of extra-cranial S-100B release has been raised. This study evaluates the post-traumatic and post-operative release kinetics of S-100B in 45 trauma victims without head injury. METHOD: Serum S-100B protein was measured on admission and every 24 hours for 4 consecutive days. RESULTS: Initial S-100B was slightly increased (median: 0.54 microg L-1) and correlated with the severity of extra-cranial trauma (p = 0.0004, Mann-Whitney test). Both severely (abdominal or chest trauma with or without bone fractures) and mildly (long bone fractures) injured showed a rapid decline of S-100B (< 0.2 microg L-1) around 72 hours post-trauma. Extra-cranial surgery caused a secondary increase of S-100B, especially in the mildly injured group (p = 0.004, Wilcoxon signed rank test). CONCLUSIONS:Extra-cranial injury results in a mild elevation of serum S-100B protein that declines rapidly (1-3 days after injury).
Authors: Juan J Egea-Guerrero; Francisco Murillo-Cabezas; Elena Gordillo-Escobar; Ana Rodríguez-Rodríguez; Judy Enamorado-Enamorado; Jaume Revuelto-Rey; María Pacheco-Sánchez; Antonio León-Justel; Jose M Domínguez-Roldán; Angel Vilches-Arenas Journal: J Neurotrauma Date: 2013-08-28 Impact factor: 5.269
Authors: Henrik Zetterberg; Michael Jonsson; Abdullah Rasulzada; Cornel Popa; Ewa Styrud; Max Albert Hietala; Lars Rosengren; Anders Wallin; Kaj Blennow Journal: Br J Sports Med Date: 2007-05-11 Impact factor: 13.800
Authors: Gretchen M Brophy; Jose A Pineda; Linda Papa; Stephen B Lewis; Alex B Valadka; H Julia Hannay; Shelley C Heaton; Jason A Demery; Ming Cheng Liu; Joseph J Tepas; Andrea Gabrielli; Steven Robicsek; Kevin K W Wang; Claudia S Robertson; Ronald L Hayes Journal: J Neurotrauma Date: 2009-04 Impact factor: 5.269