| Literature DB >> 17059883 |
Fanwei Meng1, Ling Shi, Xuan Cheng, Ning Hou, Yongliang Wang, Yan Teng, Anming Meng, Xiao Yang.
Abstract
Brain microvascular endothelial cells (ECs) have unique characteristics distinguished from peripheral ECs and play important roles in blood-brain barrier (BBB). To investigate the physiological control of the brain ECs, we generated a transgenic mouse line in which the expression of Cre recombinase was driven by the promoter of the mouse surfactant protein A (SP-A) gene. The Cre activity was detected in blood vessels of brain, alveolar type II cells of lung and epithelium of gland stomach. In brain ECs, the Cre activity started at embryonic day 11.5, indicating that the subpopulation of ECs in brain could be molecularly defined at early embryonic stages. The use of SP-A-Cre mice should facilitate analysis of gene function in the brain ECs.Entities:
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Year: 2006 PMID： 17059883 DOI： 10.1016/j.matbio.2006.09.003
Source DB: PubMed Journal: Matrix Biol ISSN： 0945-053X Impact factor: 11.583