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Literature DB >> 1705880

Kainate activated single channel currents as revealed by domoic acid.

M Sciancalepore¹, Z Gałdzicki, X Zheng, O Moran.

Abstract

We have studied the properties of kainic acid receptor-activated channels using domoic acid as an agonist. Similarities of the electrophysiological, pharmacological and noise properties of domoic acid and kainic acid-evoked currents confirm that domoate is a potent and specific agonist of the kainate receptor. Single-channel properties of domoic acid-evoked currents were directly determined from outside-out membrane patches for the first time, and results were compared with those obtained by fluctuation analysis of macroscopic currents. Small conductance cationic-selective channels of approximately 4 pS and a mean open time of 2 to 3 ms were detected using both methods.

Entities: Chemical

Mesh：

Substances：

Year: 1990 PMID： 1705880 DOI： 10.1007/bf00185087

Source DB: PubMed Journal: Eur Biophys J ISSN： 0175-7571 Impact factor: 1.733

23 in total

1. A kainic acid receptor from frog brain purified using domoic acid affinity chromatography.

Authors: D R Hampson; R J Wenthold
Journal: J Biol Chem Date: 1988-02-15 Impact factor: 5.157

2. Cloning by functional expression of a member of the glutamate receptor family.

Authors: M Hollmann; A O'Shea-Greenfield; S W Rogers; S Heinemann
Journal: Nature Date: 1989-12-07 Impact factor: 49.962

Review 3. Excitatory amino acid transmitters.

Authors: J C Watkins; R H Evans
Journal: Annu Rev Pharmacol Toxicol Date: 1981 Impact factor: 13.820

2. Repeated low level domoic acid exposure increases CA1 VGluT1 levels, but not bouton density, VGluT2 or VGAT levels in the hippocampus of adult mice.

Authors: Caitlin E Moyer; Emma M Hiolski; David J Marcinek; Kathi A Lefebvre; Donald R Smith; Yi Zuo
Journal: Harmful Algae Date: 2018-09-05 Impact factor: 4.273

Review 3. Domoic acid toxicologic pathology: a review.

Authors: Olga M Pulido
Journal: Mar Drugs Date: 2008-05-28 Impact factor: 5.118

3 in total

Kainate activated single channel currents as revealed by domoic acid.

1. A kainic acid receptor from frog brain purified using domoic acid affinity chromatography.

2. Cloning by functional expression of a member of the glutamate receptor family.

Review 3. Excitatory amino acid transmitters.

Review 4. The physiology of excitatory amino acids in the vertebrate central nervous system.

5. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

6. Changes of N-methyl-D-aspartate activated channels of cerebellar granule cells with days in culture.

7. Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones.

8. N-methyl-D-aspartate-activated channels of mouse central neurones in magnesium-free solutions.

9. Noise and single channels activated by excitatory amino acids in rat cerebellar granule neurones.

10. Multiple-conductance channels activated by excitatory amino acids in cerebellar neurons.

1. Voltage dependent calcium channels in cerebellar granule cell primary cultures.

2. Repeated low level domoic acid exposure increases CA1 VGluT1 levels, but not bouton density, VGluT2 or VGAT levels in the hippocampus of adult mice.

Review 3. Domoic acid toxicologic pathology: a review.