R James Pearson1, Thomas Wilson, Rui Wang. 1. Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5. jpearson2112@yahoo.ca
Abstract
PURPOSE: Hydrogen Sulfide has been found to be produced endogenously in amounts that cause vasodilatation. The purpose of this review is to outline the effects of hydrogen sulfide as a gasotransmitter. METHODS: This article is a summary of work done in Dr. Rui Wang's laboratory and a comprehensive review of H2S on the Pub-Med website. PRINCIPLE FINDINGS: One of the specific cellular targets of hydrogen sulfide is the K(ATP) channel protein which produces vasodilatation. The other gasotransmitters like NO (nitric oxide) interact with hydrogen sulfide in complex ways. This action could be important in hypertension and other vascular diseases. CONCLUSION: Gasotransmitter research is relevant to the pathophysiology of a number of cardiovascular disease processes.
PURPOSE:Hydrogen Sulfide has been found to be produced endogenously in amounts that cause vasodilatation. The purpose of this review is to outline the effects of hydrogen sulfide as a gasotransmitter. METHODS: This article is a summary of work done in Dr. Rui Wang's laboratory and a comprehensive review of H2S on the Pub-Med website. PRINCIPLE FINDINGS: One of the specific cellular targets of hydrogen sulfide is the K(ATP) channel protein which produces vasodilatation. The other gasotransmitters like NO (nitric oxide) interact with hydrogen sulfide in complex ways. This action could be important in hypertension and other vascular diseases. CONCLUSION: Gasotransmitter research is relevant to the pathophysiology of a number of cardiovascular disease processes.
Authors: Christopher F Toombs; Michael A Insko; Edward A Wintner; Thomas L Deckwerth; Helen Usansky; Khurram Jamil; Brahm Goldstein; Michael Cooreman; Csaba Szabo Journal: Br J Clin Pharmacol Date: 2010-06 Impact factor: 4.335
Authors: John W Elrod; John W Calvert; Joanna Morrison; Jeannette E Doeller; David W Kraus; Ling Tao; Xiangying Jiao; Rosario Scalia; Levente Kiss; Csaba Szabo; Hideo Kimura; Chi-Wing Chow; David J Lefer Journal: Proc Natl Acad Sci U S A Date: 2007-09-18 Impact factor: 11.205