Literature DB >> 17057867

Spirocyclic helical compounds as binding agents for bulged RNA, including HIV-2 TAR.

Ziwei Xiao1, Na Zhang, Yiqing Lin, Graham B Jones, Irving H Goldberg.   

Abstract

Based on fluorescence binding studies and 1D 1H NMR studies, designed synthetic analogues of NCSi-gb bind specifically with two-base bulged RNA, including HIV-2 TAR RNA, making them potential lead compounds for antiviral drug development.

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Year:  2006        PMID: 17057867     DOI: 10.1039/b610007d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  3 in total

1.  Solution structure of a designed spirocyclic helical ligand binding at a two-base bulge site in DNA.

Authors:  Na Zhang; Yiqing Lin; Ziwei Xiao; Graham B Jones; Irving H Goldberg
Journal:  Biochemistry       Date:  2007-03-28       Impact factor: 3.162

2.  Small molecule ligands for bulged RNA secondary structures.

Authors:  S Todd Meyer; Paul J Hergenrother
Journal:  Org Lett       Date:  2009-09-17       Impact factor: 6.005

3.  Designed DNA probes from the neocarzinostatin family: impact of glycosyl linkage stereochemistry on bulge base binding.

Authors:  Dong Ma; Yiqing Lin; Ziwei Xiao; Lizzy Kappen; Irving H Goldberg; Amy E Kallmerten; Graham B Jones
Journal:  Bioorg Med Chem       Date:  2009-02-10       Impact factor: 3.641

  3 in total

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