Literature DB >> 17057754

The twentieth century struggle to decipher insulin signalling.

Philip Cohen1.   

Abstract

Following the discovery of insulin, it took the rest of the twentieth century to understand how this hormone regulates intracellular metabolism. What are the main discoveries that led to our current understanding of this process? And how is this new knowledge being exploited in an attempt to develop improved drugs to treat the epidemic of type-2 diabetes?

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17057754     DOI： 10.1038/nrm2043

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  64 in total

1.  Energy Homeostasis Control in Drosophila Adipokinetic Hormone Mutants.

Authors:  Martina Gáliková; Max Diesner; Peter Klepsatel; Philip Hehlert; Yanjun Xu; Iris Bickmeyer; Reinhard Predel; Ronald P Kühnlein
Journal:  Genetics       Date:  2015-08-14       Impact factor: 4.562

2.  Trichostatin A blocks aldosterone-induced Na+ transport and control of serum- and glucocorticoid-inducible kinase 1 in cortical collecting duct cells.

Authors:  Morag K Mansley; Andrew J Roe; Sarah L Francis; Jason H Gill; Matthew A Bailey; Stuart M Wilson
Journal:  Br J Pharmacol       Date:  2019-10-25       Impact factor: 8.739

3.  NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer.

Authors:  Hifzur R Siddique; Douglas E Feldman; Chia-Lin Chen; Vasu Punj; Hiroshi Tokumitsu; Keigo Machida
Journal:  Hepatology       Date:  2015-08-28       Impact factor: 17.425

4.  Chromium supplementation improved post-stroke brain infarction and hyperglycemia.

Authors:  Wen-Ying Chen; Frank Chiahung Mao; Chia-Hsin Liu; Yu-Hsiang Kuan; Nai-Wei Lai; Chih-Cheng Wu; Chun-Jung Chen
Journal:  Metab Brain Dis       Date:  2015-10-19       Impact factor: 3.584

Review 5.  Mechanisms of Insulin Action and Insulin Resistance.

Authors:  Max C Petersen; Gerald I Shulman
Journal:  Physiol Rev       Date:  2018-10-01       Impact factor: 37.312

Review 6.  Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis.

Authors:  P H Sugden; S J Fuller; S C Weiss; A Clerk
Journal:  Br J Pharmacol       Date:  2008-01-21       Impact factor: 8.739

7.  Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3.

Authors:  Mark Larance; Alexander F Rowland; Kyle L Hoehn; David T Humphreys; Thomas Preiss; Michael Guilhaus; David E James
Journal:  Mol Cell Proteomics       Date:  2010-01-05       Impact factor: 5.911

8.  A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle.

Authors:  Erin L Glynn; Heidi L Lujan; Victoria J Kramer; Micah J Drummond; Stephen E DiCarlo; Blake B Rasmussen
Journal:  Appl Physiol Nutr Metab       Date:  2008-02       Impact factor: 2.665

9.  SGK1 activity in Na+ absorbing airway epithelial cells monitored by assaying NDRG1-Thr346/356/366 phosphorylation.

Authors:  S K Inglis; M Gallacher; S G Brown; N McTavish; J Getty; E M Husband; J T Murray; S M Wilson
Journal:  Pflugers Arch       Date:  2008-09-12       Impact factor: 3.657

10.  Differential 14-3-3 affinity capture reveals new downstream targets of phosphatidylinositol 3-kinase signaling.

Authors:  Fanny Dubois; Franck Vandermoere; Aurélie Gernez; Jane Murphy; Rachel Toth; Shuai Chen; Kathryn M Geraghty; Nick A Morrice; Carol MacKintosh
Journal:  Mol Cell Proteomics       Date:  2009-08-01       Impact factor: 5.911
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.