| Literature DB >> 17057714 |
Satoshi Hirano1, Nobuhiro Suzuki, Thomas Slagsvold, Masato Kawasaki, Daniel Trambaiolo, Ryuichi Kato, Harald Stenmark, Soichi Wakatsuki.
Abstract
ESCRT-II, a complex that sorts ubiquitinated membrane proteins to lysosomes, localizes to endosomes through interaction between the Vps36 subunit's GLUE domain and phosphatidylinositides (PIs). In yeast, a ubiquitin (Ub)-interacting NZF domain is inserted in Vps36 GLUE, whereas its mammalian counterpart, Eap45 GLUE, lacks the NZF domain. In the Eap45 GLUE-Ub complex structure, Ub binds far from the proposed PI-binding site of Eap45 GLUE, suggesting their independent binding.Entities:
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Year: 2006 PMID： 17057714 DOI： 10.1038/nsmb1163
Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369