Literature DB >> 17057195

Role of the melanocortin system in inflammation.

Christian Maaser1, Klaus Kannengiesser, Torsten Kucharzik.   

Abstract

In recent years, scientific interest in melanocortins (MC) has progressively increased due to their wide range of effects and expression on various tissues. Primarily discovered as mediators of skin pigmentation, recent research has shown their important roles in various body functions, such as energy homeostasis, sexual function, and inflammation. The anti-inflammatory and immunomodulatory properties discovered so far have led to the hypothesis that alpha-melanocyte-stimulating hormone (MSH) and its cognate receptors might present potential anti-inflammatory treatment options.

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Year:  2006        PMID： 17057195     DOI： 10.1196/annals.1326.016

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  10 in total

1.  Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptor.

Authors:  Laura Gangoso; Alexandre Roulin; Anne-Lyse Ducrest; Juan Manuel Grande; Jordi Figuerola
Journal:  Oecologia       Date:  2015-04-04       Impact factor: 3.225

2.  Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse melanocortin-4 receptor (mMC4R).

Authors:  Anamika Singh; Marvin Dirain; Rachel Witek; James R Rocca; Arthur S Edison; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2013-03-25       Impact factor: 7.446

3.  The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function.

Authors:  Dominik Bettenworth; Marion Buyse; Markus Böhm; Rudolf Mennigen; Isabel Czorniak; Klaus Kannengiesser; Thomas Brzoska; Thomas A Luger; Torsten Kucharzik; Wolfram Domschke; Christian Maaser; Andreas Lügering
Journal:  Am J Pathol       Date:  2011-07-08       Impact factor: 4.307

4.  Understanding pseudo-albinism in sole (Solea senegalensis): a transcriptomics and metagenomics approach.

Authors:  Patricia I S Pinto; Cláudia C Guerreiro; Rita A Costa; Juan F Martinez-Blanch; Carlos Carballo; Francisco M Codoñer; Manuel Manchado; Deborah M Power
Journal:  Sci Rep       Date:  2019-09-20       Impact factor: 4.379

5.  The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans.

Authors:  Karin Loser; Thomas Brzoska; Vinzenz Oji; Matteo Auriemma; Maik Voskort; Verena Kupas; Lars Klenner; Cornelius Mensing; Axel Hauschild; Stefan Beissert; Thomas A Luger
Journal:  PLoS One       Date:  2010-02-01       Impact factor: 3.240

6.  Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.

Authors:  Hongchang Qu; Minying Cai; Alexander V Mayorov; Paolo Grieco; Morgan Zingsheim; Dev Trivedi; Victor J Hruby
Journal:  J Med Chem       Date:  2009-06-25       Impact factor: 7.446

7.  The melanocortin 1 receptor (Mc1r) variants do not account for the co-occurrence of Parkinson's disease and malignant melanoma.

Authors:  Sandra Elincx-Benizri; Rivka Inzelberg; Lior Greenbaum; Oren S Cohen; Gilad Yahalom; Yael Laitman; Ruth Djaldetti; Yael Orlev; Alon Scope; Esther Azizi; Eitan Friedman; Sharon Hassin-Baer
Journal:  J Mol Neurosci       Date:  2014-10-05       Impact factor: 3.444

8.  Genetic determinants of hair color and Parkinson's disease risk.

Authors:  Xiang Gao; Kelly C Simon; Jiali Han; Michael A Schwarzschild; Alberto Ascherio
Journal:  Ann Neurol       Date:  2009-01       Impact factor: 10.422

Review 9.  An evolutionary history of defensins: a role for copy number variation in maximizing host innate and adaptive immune responses.

Authors:  Lee R Machado; Barbara Ottolini
Journal:  Front Immunol       Date:  2015-03-18       Impact factor: 7.561

10.  Body pigmentation as a risk factor for the formation of intracranial aneurysms.

Authors:  Günter Schulter; Klaus Leber; Elke Kronawetter; Viktoria R Rübenbauer; Peter Konstantiniuk; Ilona Papousek
Journal:  Biomed Res Int       Date:  2014-05-22       Impact factor: 3.411
  10 in total

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