Literature DB >> 17056977

Local anesthetic-induced cardiac toxicity: a survey of contemporary practice strategies among academic anesthesiology departments.

William Corcoran1, John Butterworth, Robert S Weller, Jonathan C Beck, J C Gerancher, Timothy T Houle, Leanne Groban.   

Abstract

Though new local anesthetics (LA), effective test-dosing, and new regional anesthetic techniques may have improved the safety of regional anesthesia, the optimal management plan for LA-induced cardiac toxicity remains uncertain. Accordingly, we evaluated current approaches to LA cardiotoxicity among academic anesthesiology departments in the United States. A 19-question survey regarding regional anesthesia practices and approaches to LA cardiac toxicity was sent to the 135 academic anesthesiology departments listed by the Society of Academic Anesthesiology Chairs-Association of Anesthesiology Program Directors. Ninety-one anonymously completed questionnaires were returned, at a response rate of 67%. The respondents were categorized into groups according to the number of peripheral nerve blocks (PNBs) performed each month: >70 PNBs (38%), 51-70 PNBs (13%), 31-50 PNBs (20%), 11-30 PNBs (23%), and <10 PNBs (6%). Anesthesia practices administering >70 PNBs were 1.7-times more likely to use ropivacaine (NS), 3.9-times more likely to consider lipid emulsion infusions for resuscitation (P = 0.008), and equally as likely to have an established plan for use of invasive mechanical cardiopulmonary support in the event of LA cardiotoxicity (NS) than low-PNB volume centers. We conclude that there are differences in the management and preparedness for treatment of LA toxicity among institutions, but the safety implications of these differences are undetermined.

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Year:  2006        PMID: 17056977     DOI: 10.1213/01.ane.0000242515.03653.bb

Source DB:  PubMed          Journal:  Anesth Analg        ISSN: 0003-2999            Impact factor:   5.108


  6 in total

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Authors:  Hao Guo; He-fei Zhang; Wen-qi Xu; Qian Du; Jing Zhao; Lei-ming Ren
Journal:  Acta Pharmacol Sin       Date:  2015-06-15       Impact factor: 6.150

Review 2.  [Lipid emulsion therapy for local anaesthetic toxicity. (LipidRescue)].

Authors:  K Ott
Journal:  Anaesthesist       Date:  2010-06       Impact factor: 1.041

3.  Intravenous lipid emulsion for treatment of local anesthetic toxicity.

Authors:  M Caroline Kosh; April D Miller; Jill E Michels
Journal:  Ther Clin Risk Manag       Date:  2010-10-05       Impact factor: 2.423

4.  Lipid rescue for bupivacaine toxicity during cardiovascular procedures.

Authors:  Christopher Gallagher; Jonathan M Tan; Crista-Gaye Foster
Journal:  Heart Int       Date:  2010-06-23

5.  Regional anesthesia and lipid resuscitation for local anesthetic systemic toxicity in China: results of a survey by the orthopedic anesthesia group of the Chinese Society Of Anesthesiology.

Authors:  Mao Xu; Shanliang Jin; Zhengqian Li; Xuzhong Xu; Xiuli Wang; Lan Zhang; Zeguo Feng; Buwei Yu; Jin Liu; Xiangyang Guo
Journal:  BMC Anesthesiol       Date:  2016-01-04       Impact factor: 2.217

Review 6.  Liposomal extended-release bupivacaine for postsurgical analgesia.

Authors:  Mark Lambrechts; Michael J O'Brien; Felix H Savoie; Zongbing You
Journal:  Patient Prefer Adherence       Date:  2013-09-06       Impact factor: 2.711

  6 in total

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