| Literature DB >> 17056036 |
Liza Leventhal1, Michael R Brandt, Terri A Cummons, Michael J Piesla, Kathryn E Rogers, Heather A Harris.
Abstract
ERB-041 (2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3 benzoxazol-5-ol) is a selective estrogen receptor-beta agonist with activity in rodent models of rheumatoid arthritis and endometriosis. Clinical trials for these diseases are underway: however, the role of estrogen receptor-beta in modulating pain associated with inflammation remains unknown. These studies demonstrate that acutely administered ERB-041 is anti-hyperalgesic in preclinical models of chemical-induced and acute inflammatory pain, thus suggesting that ERB-041 may be useful for modulating pain associated with some types of inflammation.Entities:
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Year: 2006 PMID： 17056036 DOI： 10.1016/j.ejphar.2006.09.033
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432