| Literature DB >> 17055770 |
Ashutosh Chilkoti1, Trine Christensen, J Andrew MacKay.
Abstract
Elastin-like polypeptides (ELPs) are artificial polypeptides, derived from Val-Pro-Gly-Xaa-Gly (VPGXG) pentapeptide repeats found in human tropoelastin, that reversibly coacervate above a critical temperature. Genetically encodable ELPs are monodisperse, stimuli responsive, and biocompatible, properties that make them attractive for drug delivery and tissue engineering. The potential of ELPs to self-assemble into nanostructures in response to environmental triggers is another interesting feature of these polypeptides that promises to lead to a host of new applications.Entities:
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Year: 2006 PMID： 17055770 PMCID： PMC3732176 DOI： 10.1016/j.cbpa.2006.10.010
Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822