| Literature DB >> 17055724 |
Venkata R Doppalapudi1, Nancy Tryder, Lingna Li, Teresa Aja, David Griffith, Francesca-Fang Liao, Giovanni Roxas, Mysore P Ramprasad, Curt Bradshaw, Carlos F Barbas.
Abstract
Aryl sulfonamide-based endothelin antagonists were synthesized and covalently linked to the reactive lysine of the m38C2 antibody to create a series of CovX-Bodies. These chemically programmed antibodies behaved as potent endothelin receptor antagonists in vitro and had antitumor efficacy in a prostate cancer xenograft model which, on a molar basis, far exceeded the activity of the parent small molecule.Entities:
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Year: 2006 PMID： 17055724 DOI： 10.1016/j.bmcl.2006.10.009
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823