| Literature DB >> 17055267 |
Naoaki Fujii1, Jose J Haresco, Kathleen A P Novak, Robert M Gage, Nicoletta Pedemonte, David Stokoe, Irwin D Kuntz, R Kiplin Guy.
Abstract
Novel small molecules were designed to specifically target the ligand-binding pocket of a PDZ domain. Iterative molecular docking and modeling allowed the design of an indole scaffold 10a as a reversible inhibitor of ligand binding. The 10a scaffold inhibited the interaction between MAGI-3 and PTEN and showed cellular activities that are consistent with the inhibition of NHERF-1 function.Entities:
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Year: 2006 PMID： 17055267 DOI： 10.1016/j.bmcl.2006.10.006
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823