| Literature DB >> 17055049 |
Akira Shimada1, Yasuhide Hayashi, Mizuho Ogasawara, Myoung-Ja Park, Masahiko Katoh, Hisanori Minakami, Toshiyuki Kitoh, Seiji Kojima, Keisei Kawa, Hirokazu Kimura.
Abstract
Down syndrome (DS) patients are frequently complicated with infections, autoimmune phenomena and hematological disorders, including transient abnormal myelopoiesis (TAM) in infancy and acute megakaryoblastic leukaemia (AMKL) in later life. In this study, serum levels of cytokines from 23 TAM and 15 AMKL patients were examined using the highly sensitive microsphere fluorescence system. Statistical differences between DS neonates with or without TAM were found in IL-1beta [median 7.0 pg/ml (0.34-271.6) verses 0.05 pg/ml (0.0-2.4), p=0.034], TNF-alpha [8.11 pg/ml (0.1-253.0) verses 0.41 pg/ml (0.1-1.5), p=0.041], and IFN-gamma [20.0 pg/ml (0.14-406.3) verses 1.5 pg/ml (0.14-5.79), p=0.036]. Moreover, abnormal inflammatory cytokinemia was also found in myelodysplastic syndrome (MDS) and AMKL with DS. These abnormal cytokinemia may have a role in the pathophysiology of TAM, MDS and AMKL in DS, especially in liver fibrosis or myelofibrosis.Entities:
Mesh：
Substances：
Year: 2006 PMID： 17055049 DOI： 10.1016/j.leukres.2006.09.008
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156