BACKGROUND: Visfatin is a recently described adipose tissue derived hormone whose role in humans remains largely unknown. OBJECTIVES: To determine visfatin's relationship to lipoproteins and body composition parameters in Asian Indians and Caucasians. DESIGN: A cross-sectional study. PATIENTS: Men and women living in Montreal, Canada between the ages of 20 and 60 years were recruited for participation in this study. Subjects were excluded if they had a history of CVD or were taking lipid lowering medication. Individuals identified themselves as Asian Indian or Caucasian. MEASUREMENTS: Anthropometric measurements were collected including weight, height, waist circumference, hip circumference and body fat percentage (BF%). Serum samples were analysed for total cholesterol, HDL-C, apoA1, apoB and visfatin. RESULTS: There was no difference in visfatin levels between Indian and Caucasian men (64.50 +/- 3.98 ng/ml vs 73.01 +/- 6.45 ng/ml, ns, respectively) and Indian and Caucasian women (59.03 +/- 5.71 ng/ml vs 77.70 +/- 7.63 ng/ml, ns, respectively), despite large differences in BF%, apoB and the apoB/apoA1 ratio. Visfatin correlated positively to HDL-C and apoA1 in the Indian men (R = 0.42, P = 0.004 and R = 0.48, P = 0.003) and Indian women (R = 0.46, P = 0.05 and R = 0.59, P = 0.01). CONCLUSION: Visfatin concentrations may be related to HDL metabolism in Asian Indian immigrants.
BACKGROUND:Visfatin is a recently described adipose tissue derived hormone whose role in humans remains largely unknown. OBJECTIVES: To determine visfatin's relationship to lipoproteins and body composition parameters in Asian Indians and Caucasians. DESIGN: A cross-sectional study. PATIENTS: Men and women living in Montreal, Canada between the ages of 20 and 60 years were recruited for participation in this study. Subjects were excluded if they had a history of CVD or were taking lipid lowering medication. Individuals identified themselves as Asian Indian or Caucasian. MEASUREMENTS: Anthropometric measurements were collected including weight, height, waist circumference, hip circumference and body fat percentage (BF%). Serum samples were analysed for total cholesterol, HDL-C, apoA1, apoB and visfatin. RESULTS: There was no difference in visfatin levels between Indian and Caucasian men (64.50 +/- 3.98 ng/ml vs 73.01 +/- 6.45 ng/ml, ns, respectively) and Indian and Caucasian women (59.03 +/- 5.71 ng/ml vs 77.70 +/- 7.63 ng/ml, ns, respectively), despite large differences in BF%, apoB and the apoB/apoA1 ratio. Visfatin correlated positively to HDL-C and apoA1 in the Indian men (R = 0.42, P = 0.004 and R = 0.48, P = 0.003) and Indian women (R = 0.46, P = 0.05 and R = 0.59, P = 0.01). CONCLUSION:Visfatin concentrations may be related to HDL metabolism in Asian Indian immigrants.
Authors: Ping Wang; Marleen M J van Greevenbroek; Freek G Bouwman; Martijn C G J Brouwers; Carla J H van der Kallen; Egbert Smit; Jaap Keijer; Edwin C M Mariman Journal: Pflugers Arch Date: 2007-04-12 Impact factor: 3.657
Authors: Kirsty C McGee; Alison L Harte; Nancy F da Silva; Nasser Al-Daghri; Steven J Creely; Christine M Kusminski; Gyanendra Tripathi; Paul L Levick; Manish Khanolkar; Marc Evans; Madhu V Chittari; Vinod Patel; Sudhesh Kumar; Philip G McTernan Journal: PLoS One Date: 2011-06-09 Impact factor: 3.240