Literature DB >> 17054075

Altered transcriptional activity of human endogenous retroviruses in neuroepithelial cells after infection with Toxoplasma gondii.

Oliver Frank1, Lorraine Jones-Brando, Christine Leib-Mosch, Robert Yolken, Wolfgang Seifarth.   

Abstract

Human endogenous retroviruses (HERVs) arose in antiquity from stable integration into the human genome. The mechanism for activation of HERVs has not been fully elucidated. Toxoplasmosis, caused by Toxoplasma gondii, is a medically important parasitic infection with worldwide distribution. To search for a tentative link between toxoplasmosis and HERV activation, HERV expression profiles of human neuroepithelial SK-N-MC cells infected with T. gondii were analyzed. Increased transcriptional activity of class I, II, and III HERV elements was observed in infected cells, suggesting that T. gondii can influence the transcription of HERVs in neuronal cells.

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Year:  2006        PMID： 17054075     DOI： 10.1086/508496

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  23 in total

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2.  Differential effects of three canonical Toxoplasma strains on gene expression in human neuroepithelial cells.

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3.  Mobile DNA and evolution in the 21st century.

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Review 5.  Human endogenous retroviruses and the nervous system.

Authors:  Renée N Douville; Avindra Nath
Journal:  Handb Clin Neurol       Date:  2014

6.  Activation of elements in HERV-W family by caffeine and aspirin.

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Journal:  Virus Genes       Date:  2013-06-28       Impact factor: 2.332

7.  Transcriptional derepression of the ERVWE1 locus following influenza A virus infection.

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Journal:  J Virol       Date:  2014-01-29       Impact factor: 5.103

Review 8.  A review of vulnerability and risks for schizophrenia: Beyond the two hit hypothesis.

Authors:  Justin Davis; Harris Eyre; Felice N Jacka; Seetal Dodd; Olivia Dean; Sarah McEwen; Monojit Debnath; John McGrath; Michael Maes; Paul Amminger; Patrick D McGorry; Christos Pantelis; Michael Berk
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9.  Implication of the env gene of the human endogenous retrovirus W family in the expression of BDNF and DRD3 and development of recent-onset schizophrenia.

Authors:  WenJie Huang; Shan Li; YuanMing Hu; Honglian Yu; Feng Luo; Qi Zhang; Fan Zhu
Journal:  Schizophr Bull       Date:  2010-01-25       Impact factor: 9.306

10.  Human Endogenous Retroviruses: Residues of Ancient Times Are Differentially Expressed in Crohn's Disease.

Authors:  Thomas Klag; Lioba Courth; Maureen J Ostaff; German Ott; Eduard F Stange; Nisar P Malek; Wolfgang Seifarth; Jan Wehkamp
Journal:  Inflamm Intest Dis       Date:  2018-11-21
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