M Brimacombe1, X Ming, M Lamendola. 1. Department of Preventive Medicine, New Jersey Medical School - UMDNJ, Newark, NJ, USA. brimacmb@umdnj.edu
Abstract
OBJECTIVES: Prenatal and birth history as potential sources of risk factors in relation to the onset of autism were examined. METHODS: A cohort of 164 families of autistic children referred to The Autism Center at New Jersey Medical School-UMDNJ, Newark, New Jersey, over a two-year period was studied. Intake prenatal and birth history information was obtained from each family and reviewed by a clinician. RESULTS: Prevalence rates in this cohort for vaginal bleeding, prolonged labor and prematurity were higher than comparable rates reported nationally and in New Jersey. Clustering of multiple prenatal risk factors was observed. This clustering was associated with the age of the mother, but uncorrelated with birth order. CONCLUSIONS: These findings support the general hypothesis that systemic problems at the prenatal stage may form a distinct dimension of risk associated with autism.
OBJECTIVES: Prenatal and birth history as potential sources of risk factors in relation to the onset of autism were examined. METHODS: A cohort of 164 families of autisticchildren referred to The Autism Center at New Jersey Medical School-UMDNJ, Newark, New Jersey, over a two-year period was studied. Intake prenatal and birth history information was obtained from each family and reviewed by a clinician. RESULTS: Prevalence rates in this cohort for vaginal bleeding, prolonged labor and prematurity were higher than comparable rates reported nationally and in New Jersey. Clustering of multiple prenatal risk factors was observed. This clustering was associated with the age of the mother, but uncorrelated with birth order. CONCLUSIONS: These findings support the general hypothesis that systemic problems at the prenatal stage may form a distinct dimension of risk associated with autism.
Authors: K B Nelson; J K Grether; L A Croen; J M Dambrosia; B F Dickens; L L Jelliffe; R L Hansen; T M Phillips Journal: Ann Neurol Date: 2001-05 Impact factor: 10.422
Authors: Susan L Connors; Dorothy E Crowell; Charles G Eberhart; Joshua Copeland; Craig J Newschaffer; Sarah J Spence; Andrew W Zimmerman Journal: J Child Neurol Date: 2005-11 Impact factor: 1.987
Authors: P F Bolton; M Murphy; H Macdonald; B Whitlock; A Pickles; M Rutter Journal: J Am Acad Child Adolesc Psychiatry Date: 1997-02 Impact factor: 8.829
Authors: Lonnie Zwaigenbaum; Peter Szatmari; Marshall B Jones; Susan E Bryson; Joanna E MacLean; William J Mahoney; Giampiero Bartolucci; Lawrence Tuff Journal: J Am Acad Child Adolesc Psychiatry Date: 2002-05 Impact factor: 8.829
Authors: Laura A Schieve; Catherine Rice; Owen Devine; Matthew J Maenner; Li-Ching Lee; Robert Fitzgerald; Martha S Wingate; Diana Schendel; Sydney Pettygrove; Kim van Naarden Braun; Maureen Durkin Journal: Ann Epidemiol Date: 2011-10-13 Impact factor: 3.797
Authors: Cheryl K Walker; Paula Krakowiak; Alice Baker; Robin L Hansen; Sally Ozonoff; Irva Hertz-Picciotto Journal: JAMA Pediatr Date: 2015-02 Impact factor: 16.193
Authors: Catherine Limperopoulos; Haim Bassan; Nancy R Sullivan; Janet S Soul; Richard L Robertson; Marianne Moore; Steven A Ringer; Joseph J Volpe; Adré J du Plessis Journal: Pediatrics Date: 2008-04 Impact factor: 7.124