PURPOSE OF REVIEW: The aim of this review is to summarize the most recent developments in the area of detection of fetomaternal hemorrhage by flow cytometry. RECENT FINDINGS: Maternal red blood cell chimerism is readily detectable by flow cytometry. Fetal and maternal red blood cells differ in their content of fetal hemoglobin (alpha2gamma2). Fetal red blood cells contain fetal hemoglobin, and normal maternal red blood cells contain some percentage of fetal hemoglobin in a background of normal adult hemoglobin. All blood group systems with allelic differences between mother and fetus are readily applicable for detection of fetomaternal hemorrhage by fetal hemoglobin. SUMMARY: Fetal hemoglobin for detection of fetomaternal hemorrhage is an accurate clinical diagnostic procedure for investigation of anemia in fetus and newborn.
PURPOSE OF REVIEW: The aim of this review is to summarize the most recent developments in the area of detection of fetomaternal hemorrhage by flow cytometry. RECENT FINDINGS: Maternal red blood cell chimerism is readily detectable by flow cytometry. Fetal and maternal red blood cells differ in their content of fetal hemoglobin (alpha2gamma2). Fetal red blood cells contain fetal hemoglobin, and normal maternal red blood cells contain some percentage of fetal hemoglobin in a background of normal adult hemoglobin. All blood group systems with allelic differences between mother and fetus are readily applicable for detection of fetomaternal hemorrhage by fetal hemoglobin. SUMMARY: Fetal hemoglobin for detection of fetomaternal hemorrhage is an accurate clinical diagnostic procedure for investigation of anemia in fetus and newborn.
Authors: Uma M Reddy; Robert Goldenberg; Robert Silver; Gordon C S Smith; Richard M Pauli; Ronald J Wapner; Jason Gardosi; Halit Pinar; Marjorie Grafe; Michael Kupferminc; Ingela Hulthén Varli; Jan Jaap H M Erwich; Ruth C Fretts; Marian Willinger Journal: Obstet Gynecol Date: 2009-10 Impact factor: 7.623
Authors: Demet Nalbant; Prasad Bhandary; Nell I Matthews; Robert L Schmidt; Anna Bogusiewicz; Gretchen A Cress; M Bridget Zimmerman; Ronald G Strauss; Donald M Mock; John A Widness Journal: Pediatr Res Date: 2013-09-03 Impact factor: 3.756