BACKGROUND AND PURPOSE: The impact of lipometabolic and glucometabolic disturbances on stroke incidence remains to be characterized in detail. We investigated relations of a comprehensive panel of baseline lipometabolic and glucometabolic variables to incident fatal and nonfatal stroke or transient ischemic attack (TIA), and stroke subtypes. METHODS: A community-based prospective study of 2313 middle-aged men invited to a health survey at age 50. RESULTS: During a follow-up of up to 32 years, 421 developed stroke or TIA. In Cox proportional hazards analyses adjusting for treatment with cardiovascular drugs at baseline, 1-standard deviation increases in body mass index, systolic and diastolic blood pressures, serum proinsulin, and lipoprotein(a) were associated with 11 to 35% increased risk for subsequent stroke/TIA. Electrocardiographic left ventricular hypertrophy and smoking were also associated with a higher risk for stroke/TIA. Essentially the same variables were related to brain infarction/TIA. Higher proportions of palmitic (16:0), palmitoleic (16:1), and oleic acid (18:1) in cholesterol esters were associated with an increased risk, whereas a higher proportion of linoleic acid (18:2 n-6) was protective against stroke/TIA. Further adjusting all models also for hypertension, diabetes, the metabolic syndrome, serum cholesterol, atrial fibrillation, cardiovascular disease, smoking, and physical activity, essentially the same pattern was observed. CONCLUSIONS: Indices of an unhealthy dietary fat intake and a high serum lipoprotein (a) level predicted fatal and nonfatal stroke/TIA independently of established risk factors in a community-based sample of middle-aged men followed for 32 years.
BACKGROUND AND PURPOSE: The impact of lipometabolic and glucometabolic disturbances on stroke incidence remains to be characterized in detail. We investigated relations of a comprehensive panel of baseline lipometabolic and glucometabolic variables to incident fatal and nonfatal stroke or transient ischemic attack (TIA), and stroke subtypes. METHODS: A community-based prospective study of 2313 middle-aged men invited to a health survey at age 50. RESULTS: During a follow-up of up to 32 years, 421 developed stroke or TIA. In Cox proportional hazards analyses adjusting for treatment with cardiovascular drugs at baseline, 1-standard deviation increases in body mass index, systolic and diastolic blood pressures, serum proinsulin, and lipoprotein(a) were associated with 11 to 35% increased risk for subsequent stroke/TIA. Electrocardiographic left ventricular hypertrophy and smoking were also associated with a higher risk for stroke/TIA. Essentially the same variables were related to brain infarction/TIA. Higher proportions of palmitic (16:0), palmitoleic (16:1), and oleic acid (18:1) in cholesterol esters were associated with an increased risk, whereas a higher proportion of linoleic acid (18:2 n-6) was protective against stroke/TIA. Further adjusting all models also for hypertension, diabetes, the metabolic syndrome, serum cholesterol, atrial fibrillation, cardiovascular disease, smoking, and physical activity, essentially the same pattern was observed. CONCLUSIONS: Indices of an unhealthy dietary fat intake and a high serum lipoprotein (a) level predicted fatal and nonfatal stroke/TIA independently of established risk factors in a community-based sample of middle-aged men followed for 32 years.
Authors: Amanda M Fretts; Dariush Mozaffarian; David S Siscovick; Colleen Sitlani; Bruce M Psaty; Eric B Rimm; Xiaoling Song; Barbara McKnight; Donna Spiegelman; Irena B King; Rozenn N Lemaitre Journal: Br J Nutr Date: 2014-08-27 Impact factor: 3.718
Authors: Claudia L Satizabal; Cécilia Samieri; Kendra L Davis-Plourde; Barbara Voetsch; Hugo J Aparicio; Matthew P Pase; José Rafael Romero; Catherine Helmer; Ramachandran S Vasan; Carlos S Kase; Stéphanie Debette; Alexa S Beiser; Sudha Seshadri Journal: Stroke Date: 2018-12 Impact factor: 7.914
Authors: Angela S Koh; An Pan; Renwei Wang; Andrew O Odegaard; Mark A Pereira; Jian-Min Yuan; Woon-Puay Koh Journal: Eur J Prev Cardiol Date: 2013-12-16 Impact factor: 7.804
Authors: Matti Marklund; Jason H Y Wu; Fumiaki Imamura; Liana C Del Gobbo; Amanda Fretts; Janette de Goede; Peilin Shi; Nathan Tintle; Maria Wennberg; Stella Aslibekyan; Tzu-An Chen; Marcia C de Oliveira Otto; Yoichiro Hirakawa; Helle Højmark Eriksen; Janine Kröger; Federica Laguzzi; Maria Lankinen; Rachel A Murphy; Kiesha Prem; Cécilia Samieri; Jyrki Virtanen; Alexis C Wood; Kerry Wong; Wei-Sin Yang; Xia Zhou; Ana Baylin; Jolanda M A Boer; Ingeborg A Brouwer; Hannia Campos; Paulo H M Chaves; Kuo-Liong Chien; Ulf de Faire; Luc Djoussé; Gudny Eiriksdottir; Naglaa El-Abbadi; Nita G Forouhi; J Michael Gaziano; Johanna M Geleijnse; Bruna Gigante; Graham Giles; Eliseo Guallar; Vilmundur Gudnason; Tamara Harris; William S Harris; Catherine Helmer; Mai-Lis Hellenius; Allison Hodge; Frank B Hu; Paul F Jacques; Jan-Håkan Jansson; Anya Kalsbeek; Kay-Tee Khaw; Woon-Puay Koh; Markku Laakso; Karin Leander; Hung-Ju Lin; Lars Lind; Robert Luben; Juhua Luo; Barbara McKnight; Jaakko Mursu; Toshiharu Ninomiya; Kim Overvad; Bruce M Psaty; Eric Rimm; Matthias B Schulze; David Siscovick; Michael Skjelbo Nielsen; Albert V Smith; Brian T Steffen; Lyn Steffen; Qi Sun; Johan Sundström; Michael Y Tsai; Hugh Tunstall-Pedoe; Matti I J Uusitupa; Rob M van Dam; Jenna Veenstra; W M Monique Verschuren; Nick Wareham; Walter Willett; Mark Woodward; Jian-Min Yuan; Renata Micha; Rozenn N Lemaitre; Dariush Mozaffarian; Ulf Risérus Journal: Circulation Date: 2019-05-21 Impact factor: 29.690
Authors: An Pan; Mu Chen; Rajiv Chowdhury; Jason H Y Wu; Qi Sun; Hannia Campos; Dariush Mozaffarian; Frank B Hu Journal: Am J Clin Nutr Date: 2012-10-17 Impact factor: 7.045