Literature DB >> 1705236

The antibody response in BALB/c mice to the Plasmodium falciparum circumsporozoite repetitive epitope covalently coupled to synthetic lipopeptide adjuvant.

K H Wiesmüller1, G Jung, D Gillessen, C Loffl, W G Bessler, T Böltz.   

Abstract

The repetitive epitope of Plasmodium falciparum circumsporozoite protein (Asn-Ala-Asn-Pro)3 [(NANP)3] was coupled to tripalmitoyl-S-glyceryl-cysteine (P3C) and tripalmitoyl-S-glyceryl-cysteinyl-serine (P3CS). The lipopeptide P3CS is a potent B-cell and macrophage activator. The resulting immunogenic lipopeptides were used for immunization of the low responder mouse strain BALB/c. These low molecular weight conjugates induced specific anti-(NANP)3 IgG and IgM levels without any carrier proteins or admixed adjuvants after a single administration.

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Year:  1991        PMID： 1705236      PMCID： PMC1384345     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  23 in total

1.  In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine.

Authors:  K Deres; H Schild; K H Wiesmüller; G Jung; H G Rammensee
Journal:  Nature       Date:  1989-11-30       Impact factor: 49.962

2.  Immunogenicity of synthetic peptides from circumsporozoite protein of Plasmodium falciparum.

Authors:  W R Ballou; J Rothbard; R A Wirtz; D M Gordon; J S Williams; R W Gore; I Schneider; M R Hollingdale; R L Beaudoin; W L Maloy
Journal:  Science       Date:  1985-05-24       Impact factor: 47.728

3.  Synthetic Plasmodium falciparum circumsporozoite peptides elicit heterogenous L3T4+ T cell proliferative responses in H-2b mice.

Authors:  A R Togna; G Del Giudice; A S Verdini; F Bonelli; A Pessi; H D Engers; G Corradin
Journal:  J Immunol       Date:  1986-11-01       Impact factor: 5.422

4.  Cell-mediated immune responses to vaccine peptides derived from the circumsporozoite protein of Plasmodium falciparum.

Authors:  D M Russo; J S Sundy; J F Young; H C Maguire; W P Weidanz
Journal:  J Immunol       Date:  1989-07-15       Impact factor: 5.422

5.  A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules.

Authors:  F Sinigaglia; M Guttinger; J Kilgus; D M Doran; H Matile; H Etlinger; A Trzeciak; D Gillessen; J R Pink
Journal:  Nature       Date:  1988 Dec 22-29       Impact factor: 49.962

6.  Recombinant human IL-2 overcomes genetic nonresponsiveness to malaria sporozoite peptides. Correlation of effect with biologic activity of IL-2.

Authors:  M F Good; D Pombo; M N Lunde; W L Maloy; R Halenbeck; K Koths; L H Miller; J A Berzofsky
Journal:  J Immunol       Date:  1988-08-01       Impact factor: 5.422

7.  Stimulation of human and murine adherent cells by bacterial lipoprotein and synthetic lipopeptide analogues.

Authors:  P Hoffmann; S Heinle; U F Schade; H Loppnow; A J Ulmer; H D Flad; G Jung; W G Bessler
Journal:  Immunobiology       Date:  1988-05       Impact factor: 3.144

8.  A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria.

Authors:  M E Patarroyo; R Amador; P Clavijo; A Moreno; F Guzman; P Romero; R Tascon; A Franco; L A Murillo; G Ponton
Journal:  Nature       Date:  1988-03-10       Impact factor: 49.962

9.  Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites.

Authors:  D A Herrington; D F Clyde; G Losonsky; M Cortesia; J R Murphy; J Davis; S Baqar; A M Felix; E P Heimer; D Gillessen
Journal:  Nature       Date:  1987 Jul 16-22       Impact factor: 49.962

10.  Human T cells recognize polymorphic and non-polymorphic regions of the Plasmodium falciparum circumsporozoite protein.

Authors:  M Guttinger; P Caspers; B Takacs; A Trzeciak; D Gillessen; J R Pink; F Sinigaglia
Journal:  EMBO J       Date:  1988-08       Impact factor: 11.598
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  2 in total

1.  Immunogenicity of a contiguous T-B synthetic epitope of the A/PR/8/34 influenza virus.

Authors:  T D Brumeanu; S Casares; A Bot; S Bot; C A Bona
Journal:  J Virol       Date:  1997-07       Impact factor: 5.103

2.  Identification of new cytotoxic T-cell epitopes on the 38-kilodalton lipoglycoprotein of Mycobacterium tuberculosis by using lipopeptides.

Authors:  D P da Fonseca; D Joosten; R van der Zee; D L Jue; M Singh; H M Vordermeier; H Snippe; A F Verheul
Journal:  Infect Immun       Date:  1998-07       Impact factor: 3.441
  2 in total

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