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Literature DB >> 17052243

Inhibitors of the catalytic domain of mitochondrial ATP synthase.

Abstract

An understanding of the mechanism of ATP synthase requires an explanation of how inhibitors act. The catalytic F1-ATPase domain of the enzyme has been studied extensively by X-ray crystallography in a variety of inhibited states. Four independent inhibitory sites have been identified by high-resolution structural studies. They are the catalytic site, and the binding sites for the antibiotics aurovertin and efrapeptin and for the natural inhibitor protein, IF1.

Entities: Chemical

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Year: 2006 PMID： 17052243 DOI： 10.1042/BST0340989

Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407

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Cited

13 in total

1. Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments.

Authors: Pabalu P Karunadharma; Nathan Basisty; Ying Ann Chiao; Dao-Fu Dai; Rachel Drake; Nick Levy; William J Koh; Mary J Emond; Shane Kruse; David Marcinek; Michael J Maccoss; Peter S Rabinovitch
Journal: FASEB J Date: 2015-05-14 Impact factor: 5.191

Review 2. Mitochondria from anoxia-tolerant animals reveal common strategies to survive without oxygen.

Authors: Gina L J Galli; Jeffrey G Richards
Journal: J Comp Physiol B Date: 2014-02-07 Impact factor: 2.200

3. Downregulation of the δ-subunit reduces mitochondrial ATP synthase levels, alters respiration, and restricts growth and gametophyte development in Arabidopsis.

Authors: Daniela A Geisler; Carola Päpke; Toshihiro Obata; Adriano Nunes-Nesi; Annemarie Matthes; Kay Schneitz; Eugenia Maximova; Wagner L Araújo; Alisdair R Fernie; Staffan Persson
Journal: Plant Cell Date: 2012-07-17 Impact factor: 11.277

4. The structure of the membrane extrinsic region of bovine ATP synthase.

Authors: David M Rees; Andrew G W Leslie; John E Walker
Journal: Proc Natl Acad Sci U S A Date: 2009-12-07 Impact factor: 11.205

Review 5. F1F0-ATP synthases of alkaliphilic bacteria: lessons from their adaptations.

Authors: David B Hicks; Jun Liu; Makoto Fujisawa; Terry A Krulwich
Journal: Biochim Biophys Acta Date: 2010-03-01

6. The effect of NBD-Cl in nucleotide-binding of the major subunit alpha and B of the motor proteins F1FO ATP synthase and A1AO ATP synthase.

Authors: Cornelia Hunke; Vikeramjeet Singh Tadwal; Malathy Sony Subramanian Manimekalai; Manfred Roessle; Gerhard Grüber
Journal: J Bioenerg Biomembr Date: 2010-01-16 Impact factor: 2.945

Inhibitors of the catalytic domain of mitochondrial ATP synthase.

1. Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments.

Review 2. Mitochondria from anoxia-tolerant animals reveal common strategies to survive without oxygen.

3. Downregulation of the δ-subunit reduces mitochondrial ATP synthase levels, alters respiration, and restricts growth and gametophyte development in Arabidopsis.

4. The structure of the membrane extrinsic region of bovine ATP synthase.

Review 5. F1F0-ATP synthases of alkaliphilic bacteria: lessons from their adaptations.

6. The effect of NBD-Cl in nucleotide-binding of the major subunit alpha and B of the motor proteins F1FO ATP synthase and A1AO ATP synthase.

7. Inhibition of ATP synthase by chlorinated adenosine analogue.

8. Mechanistic basis for differential inhibition of the F1Fo-ATPase by aurovertin.

9. ATP synthase: from single molecule to human bioenergetics.

10. How the regulatory protein, IF(1), inhibits F(1)-ATPase from bovine mitochondria.