Literature DB >> 17052008

[Intracranial granulocytic sarcoma in a patient with acute myeloid leukemia].

Harue Obara1, Shinjitsu Nishimura, Nakamasa Hayashi, Yoshihiro Numagami, Tomoo Inoue, Kohmei Kubo, Mitsuomi Kaimori, Michiharu Nishijima.   

Abstract

Granulocytic sarcoma (GS) is extramedullary tumor composed of immature leukemic cells. GS is presenting usually as a complication during the course of hematologic neoplasm, such as acute myeloblastic leukemia as well as myeloproliferative and myelodysplastic syndrome. The tumor was also called chroloma based on the green color of the tumorous mass. Central nervous system manifestations of GS are extremely rare. We report a 41-year-old man with acute leukemia type M7, who developed GS in the right occipital lobe after complete remission was achieved. Operative findings revealed the color of the hard tumor was greenish, which suggested the tumor was chroloma. Histological findings showed the tumor was GS. The majority of reported cases of GS in acute myeloid leukemia were M2 FAB classification and have chromosome translocation. Our patient was M7 FAB classification, not have specific chromosome translocation. GS occurrence in AML: M7 patient was extremely rare. This is the first case report of AML: M7 with GS in the central nervous system.

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Year:  2006        PMID: 17052008

Source DB:  PubMed          Journal:  No To Shinkei        ISSN: 0006-8969


  4 in total

Review 1.  Is acute myeloid leukemia a liquid tumor?

Authors:  Maro Ohanian; Stefan Faderl; Farhad Ravandi; Naveen Pemmaraju; Guillermo Garcia-Manero; Jorge Cortes; Zeev Estrov
Journal:  Int J Cancer       Date:  2013-02-04       Impact factor: 7.396

2.  Diagnosis in subdural myeloid sarcoma.

Authors:  Alan Lackey; Barbara Laing; Andrew Perkins; Michael Bryant
Journal:  Neuroradiol J       Date:  2017-01-30

3.  Extramedullary hematopoiesis presenting as a compressive cord and cerebral lesion in a patient without a significant hematologic disorder: a case report.

Authors:  Amir Saied Seddighi; Afsoun Seddighi
Journal:  J Med Case Rep       Date:  2010-10-12

4.  Multiple intracranial tuberculomas mimicking granulocytic sarcomas in acute myeloid leukemia.

Authors:  Jae Sook Ahn; Duk Hwan Yang; Yoe Kyeoung Kim; Sang Hee Cho; In Young Kim; Je Jung Lee; Ik Joo Chung; Hyeoung Joon Kim
Journal:  J Korean Med Sci       Date:  2007-09       Impact factor: 2.153

  4 in total

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