Literature DB >> 1705121

Transforming growth factor beta 1 differentially regulates alpha-fetoprotein and albumin in HuH-7 human hepatoma cells.

K Nakao1, K Nakata, S Mitsuoka, A Ohtsuru, A Ido, M Hatano, Y Sato, T Nakayama, M Shima, Y Kusumoto.   

Abstract

Transforming growth factor beta 1 (TGF-beta 1) is known to inhibit hepatocyte growth in vitro and in vivo. In this study, we analyzed the effect of TGF-beta 1 on alpha-fetoprotein (AFP) and albumin gene expression in HuH-7 human hepatoma cells. TGF-beta 1 inhibited cell growth in a dose dependent manner. The cellular secretion rate of AFP but not albumin was suppressed significantly by TGF-beta 1. TGF-beta 1 caused a significant reduction in the level of AFP mRNA. In contrast, the levels of albumin mRNA or beta-actin mRNA were not changed by TGF-beta 1. In transient transfection experiments, TGF-beta 1 resulted in selective repression of AFP promoter activity. These results suggest that TGF-beta 1 is one of the key factors involved in the differential regulation of the AFP gene and the albumin gene.

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Year:  1991        PMID： 1705121     DOI： 10.1016/0006-291x(91)91562-q

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  Changes of antigen expression on human hepatoma cell lines caused by sodium butyrate, a differentiation inducer.

Authors:  H Saito; S Tada; H Ebinuma; S Tsunematsu; T Kagawa; N Kumagai; Y Inagaki; T Watanabe; K Tsuchimoto; T Morizane
Journal:  J Gastroenterol       Date:  1994-12       Impact factor: 7.527

2.  Circulating intercellular adhesion molecule 1 predicts non-specific elevation of alpha 1-fetoprotein.

Authors:  E Falleti; C Fabris; M Pirisi; G Soardo; D Vitulli; P Toniutto; E Bartoli; N Bortolotti; F Gonano
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553

3.  Elevated urinary transforming growth factor-beta1 level as a tumour marker and predictor of poor survival in cirrhotic hepatocellular carcinoma.

Authors:  J F Tsai; J E Jeng; L Y Chuang; M L Yang; M S Ho; W Y Chang; M Y Hsieh; Z Y Lin; J H Tsai
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

4.  Clinical evaluation of urinary transforming growth factor-beta1 and serum alpha-fetoprotein as tumour markers of hepatocellular carcinoma.

Authors:  J F Tsai; J E Jeng; L Y Chuang; M L Yang; M S Ho; W Y Chang; M Y Hsieh; Z Y Lin; J H Tsai
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

5.  TGF- β Signaling Cooperates with AT Motif-Binding Factor-1 for Repression of the α -Fetoprotein Promoter.

Authors:  Nobuo Sakata; Satoshi Kaneko; Souichi Ikeno; Yutaka Miura; Hidekazu Nakabayashi; Xue-Yuan Dong; Jin-Tang Dong; Taiki Tamaoki; Naoko Nakano; Susumu Itoh
Journal:  J Signal Transduct       Date:  2014-07-03
  5 in total

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