| Literature DB >> 1705117 |
L M Blayney1, P W Gapper, A C Newby.
Abstract
We have further characterized a putative receptor-operated Ca2+ channel that is activated by histamine and guanosine 5'-[beta gamma-imido]triphosphate. Insensitivity to verapamil, diltiazem or nicardipine, but inhibition by Ni2+ and SK&F 96365, further identify the channel with receptor-mediated Ca2+ entry in intact cells. Inhibition of the channel by cyclic-GMP-dependent protein kinase may contribute to vascular relaxation in response to nitrovasodilators.Entities:
Mesh:
Substances:
Year: 1991 PMID: 1705117 PMCID: PMC1149835 DOI: 10.1042/bj2730803
Source DB: PubMed Journal: Biochem J ISSN: 0264-6021 Impact factor: 3.857