Literature DB >> 17049455

Using STN DBS and medication reduction as a strategy to treat pathological gambling in Parkinson's disease.

Fabio Bandini1, Alberto Primavera, Matteo Pizzorno, Leonardo Cocito.   

Abstract

We describe two patients with Parkinson's disease (PD) who developed clinical criteria of pathological gambling addiction in the setting of increased dopamine replacement therapy (levodopa and dopamine agonist medications). The second patient showed also signs of dopamine dysregulation syndrome, with an addiction to dopaminergic medication. Neither patients responded to the standard therapy for gambling behavior, but dramatically improved after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) and early postoperative withdrawal of dopaminergic therapy. The possible therapeutic role of subthalamic nucleus deep brain stimulation (STN-DBS) on such a disabling behavior needs to be investigated prospectively.

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Year:  2006        PMID： 17049455     DOI： 10.1016/j.parkreldis.2006.07.011

Source DB:  PubMed          Journal:  Parkinsonism Relat Disord        ISSN： 1353-8020            Impact factor:   4.891


  33 in total

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