Literature DB >> 17049336

Inhibitors of sphingolipid metabolism enzymes.

Antonio Delgado1, Josefina Casas, Amadeu Llebaria, José Luís Abad, Gemma Fabrias.   

Abstract

Sphingolipids are a family of lipids that play essential roles both as structural cell membrane components and in cell signalling. The cellular contents of the various sphingolipid species are controlled by enzymes involved in their metabolic pathways. In this context, the discovery of small chemical entities able to modify these enzyme activities in a potent and selective way should offer new pharmacological tools and therapeutic agents.

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Year:  2006        PMID: 17049336     DOI: 10.1016/j.bbamem.2006.08.017

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  55 in total

1.  RNAi-based biosynthetic pathway screens to identify in vivo functions of non-nucleic acid-based metabolites such as lipids.

Authors:  Hongjie Zhang; Nessy Abraham; Liakot A Khan; Verena Gobel
Journal:  Nat Protoc       Date:  2015-04-02       Impact factor: 13.491

2.  A novel sphingosine kinase inhibitor induces autophagy in tumor cells.

Authors:  Vladimir Beljanski; Christian Knaak; Charles D Smith
Journal:  J Pharmacol Exp Ther       Date:  2010-02-23       Impact factor: 4.030

3.  Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia.

Authors:  Sasa Stefanić; Cornelia Spycher; Laura Morf; Gemma Fabriàs; Josefina Casas; Elisabeth Schraner; Peter Wild; Adrian B Hehl; Sabrina Sonda
Journal:  J Lipid Res       Date:  2010-03-24       Impact factor: 5.922

4.  Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation.

Authors:  Michael M Ndengele; Salvatore Cuzzocrea; Emanuela Masini; M Cristina Vinci; Emanuela Esposito; Carolina Muscoli; Daniela Nicoleta Petrusca; Vincenzo Mollace; Emanuela Mazzon; Dechun Li; Irina Petrache; George M Matuschak; Daniela Salvemini
Journal:  J Pharmacol Exp Ther       Date:  2008-11-25       Impact factor: 4.030

5.  Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts.

Authors:  Richard G A Faragher; Dominic G A Burton; Patricia Majecha; Noel S Y Fong; Terence Davis; Angela Sheerin; Elizabeth L Ostler
Journal:  Age (Dordr)       Date:  2011-02-12

6.  Orm family proteins mediate sphingolipid homeostasis.

Authors:  David K Breslow; Sean R Collins; Bernd Bodenmiller; Ruedi Aebersold; Kai Simons; Andrej Shevchenko; Christer S Ejsing; Jonathan S Weissman
Journal:  Nature       Date:  2010-02-25       Impact factor: 49.962

7.  Sphingolipids Modulate Secretion of Glycosylphosphatidylinositol-Anchored Plasmodesmata Proteins and Callose Deposition.

Authors:  Arya Bagus Boedi Iswanto; Jong Cheol Shon; Kwang Hyeon Liu; Minh Huy Vu; Ritesh Kumar; Jae-Yean Kim
Journal:  Plant Physiol       Date:  2020-07-07       Impact factor: 8.340

Review 8.  Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism.

Authors:  William L Holland; Scott A Summers
Journal:  Endocr Rev       Date:  2008-05-01       Impact factor: 19.871

9.  Acid ceramidase as a therapeutic target in metastatic prostate cancer.

Authors:  Luz Camacho; Oscar Meca-Cortés; José Luis Abad; Simón García; Nuria Rubio; Alba Díaz; Toni Celià-Terrassa; Francesca Cingolani; Raquel Bermudo; Pedro L Fernández; Jerónimo Blanco; Antonio Delgado; Josefina Casas; Gemma Fabriàs; Timothy M Thomson
Journal:  J Lipid Res       Date:  2013-02-19       Impact factor: 5.922

10.  Modulation of the activity of cytosolic phospholipase A2alpha (cPLA2alpha) by cellular sphingolipids and inhibition of cPLA2alpha by sphingomyelin.

Authors:  Hiroyuki Nakamura; Shigeo Wakita; Akiko Suganami; Yutaka Tamura; Kentaro Hanada; Toshihiko Murayama
Journal:  J Lipid Res       Date:  2009-10-16       Impact factor: 5.922

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