Literature DB >> 17049325

Quantitative trait loci modulate vertebral morphology and mechanical properties in a population of 18-month-old genetically heterogeneous mice.

Grant M Reeves1, Barbara R McCreadie, Shu Chen, Andrzej T Galecki, David T Burke, Richard A Miller, Steven A Goldstein.   

Abstract

The aim of this study was to examine effects of polymorphic genes on vertebral bone morphology and mechanical properties. Genotypes from 525 18-month-old female mice were compared to geometric traits obtained from micro-computed tomography and mechanical properties from compression testing. Genetic markers were associated with traits on at least 13 different chromosomes, demonstrating the complexity of genetic control over vertebral form, function and aging.

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Year:  2006        PMID： 17049325      PMCID： PMC1852531          DOI： 10.1016/j.bone.2006.08.018

Source DB:  PubMed          Journal:  Bone        ISSN： 1873-2763            Impact factor:   4.398


  27 in total

1.  A second-stage genome scan for QTLs influencing BMD variation.

Authors:  Q-Y Huang; F-H Xu; H Shen; L-J Zhao; H-Y Deng; Y-J Liu; V Dvomyk; T Conway; K M Davies; J-L Li; Y-Z Liu; R R Recker; H-W Deng
Journal:  Calcif Tissue Int       Date:  2004-04-08       Impact factor: 4.333

Review 2.  Bone quality: understanding what matters.

Authors:  D B Burr
Journal:  J Musculoskelet Neuronal Interact       Date:  2004-06       Impact factor: 2.041

3.  Multiple-trait quantitative trait loci analysis using a large mouse sibship.

Authors:  A U Jackson; A Fornés; A Galecki; R A Miller; D T Burke
Journal:  Genetics       Date:  1999-02       Impact factor: 4.562

4.  The relationship between the structural and orthogonal compressive properties of trabecular bone.

Authors:  R W Goulet; S A Goldstein; M J Ciarelli; J L Kuhn; M B Brown; L A Feldkamp
Journal:  J Biomech       Date:  1994-04       Impact factor: 2.712

5.  Empirical threshold values for quantitative trait mapping.

Authors:  G A Churchill; R W Doerge
Journal:  Genetics       Date:  1994-11       Impact factor: 4.562

Review 6.  Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone.

Authors:  S A Goldstein; R Goulet; D McCubbrey
Journal:  Calcif Tissue Int       Date:  1993       Impact factor: 4.333

7.  Mapping tissue-specific genes correlated with age-dependent changes in protein stability and function.

Authors:  Kathleen C Wisser; Joseph A Schauerte; David T Burke; Andrzej Galecki; Shu Chen; Richard A Miller; Ari Gafni
Journal:  Arch Biochem Biophys       Date:  2004-12-01       Impact factor: 4.013

8.  Quantitative trait loci that modulate femoral mechanical properties in a genetically heterogeneous mouse population.

Authors:  Suzanne K Volkman; Andrzej T Galecki; David T Burke; Richard A Miller; Steven A Goldstein
Journal:  J Bone Miner Res       Date:  2004-05-10       Impact factor: 6.741

Review 9.  Bone quality: a determinant for certain risk factors for bone fragility.

Authors:  C M Schnitzler
Journal:  Calcif Tissue Int       Date:  1993       Impact factor: 4.333

10.  Health-related quality of life after osteoporotic fractures.

Authors:  I Hallberg; A M Rosenqvist; L Kartous; O Löfman; O Wahlström; G Toss
Journal:  Osteoporos Int       Date:  2004-03-25       Impact factor: 4.507
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  9 in total

1.  Preservation of femoral bone thickness in middle age predicts survival in genetically heterogeneous mice.

Authors:  Richard A Miller; Jaclynn Kreider; Andrzej Galecki; Steven A Goldstein
Journal:  Aging Cell       Date:  2011-03-22       Impact factor: 9.304

2.  Weak genetic relationship between trabecular bone morphology and obesity in mice.

Authors:  E Ann Carson; Jane P Kenney-Hunt; Mihaela Pavlicev; Kristine A Bouckaert; Alex J Chinn; Matthew J Silva; James M Cheverud
Journal:  Bone       Date:  2012-04-06       Impact factor: 4.398

3.  Trabecular bone loss at a distant skeletal site following noninvasive knee injury in mice.

Authors:  Blaine A Christiansen; Armaun J Emami; David P Fyhrie; Patrick B Satkunananthan; Michael R Hardisty
Journal:  J Biomech Eng       Date:  2015-01       Impact factor: 2.097

4.  Fourier transform infrared imaging microspectroscopy and tissue-level mechanical testing reveal intraspecies variation in mouse bone mineral and matrix composition.

Authors:  Hayden-William Courtland; Philip Nasser; Andrew B Goldstone; Lyudmila Spevak; Adele L Boskey; Karl J Jepsen
Journal:  Calcif Tissue Int       Date:  2008-10-15       Impact factor: 4.333

5.  Adult Brtl/+ mouse model of osteogenesis imperfecta demonstrates anabolic response to sclerostin antibody treatment with increased bone mass and strength.

Authors:  B P Sinder; L E White; J D Salemi; M S Ominsky; M S Caird; J C Marini; K M Kozloff
Journal:  Osteoporos Int       Date:  2014-05-07       Impact factor: 4.507

Review 6.  Trabecular bone mechanical properties in patients with fragility fractures.

Authors:  Jaclynn M Kreider; Steven A Goldstein
Journal:  Clin Orthop Relat Res       Date:  2009-02-27       Impact factor: 4.176

7.  Age Dependence of Systemic Bone Loss and Recovery Following Femur Fracture in Mice.

Authors:  Armaun J Emami; Chrisoula A Toupadakis; Stephanie M Telek; David P Fyhrie; Clare E Yellowley; Blaine A Christiansen
Journal:  J Bone Miner Res       Date:  2018-09-24       Impact factor: 6.741

8.  Loss of BMP signaling mediated by BMPR1A in osteoblasts leads to differential bone phenotypes in mice depending on anatomical location of the bones.

Authors:  Honghao Zhang; Yanshuai Zhang; Masahiko Terajima; Genevieve Romanowicz; Yangjia Liu; Maiko Omi; Erin Bigelow; Danese M Joiner; Erik I Waldorff; Peizhi Zhu; Mekhala Raghavan; Michelle Lynch; Nobuhiro Kamiya; Rongqing Zhang; Karl J Jepsen; Steve Goldstein; Michael D Morris; Mitsuo Yamauchi; David H Kohn; Yuji Mishina
Journal:  Bone       Date:  2020-05-01       Impact factor: 4.398

9.  Dissection of complex adult traits in a mouse synthetic population.

Authors:  David T Burke; Kenneth M Kozloff; Shu Chen; Joshua L West; Jodi M Wilkowski; Steven A Goldstein; Richard A Miller; Andrzej T Galecki
Journal:  Genome Res       Date:  2012-05-15       Impact factor: 9.043
  9 in total

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