Literature DB >> 17048857

Improving foldamer synthesis through protecting group induced unfolding of aromatic oligoamides.

Aimin Zhang1, Joseph S Ferguson, Kazuhiro Yamato, Chong Zheng, Bing Gong.   

Abstract

The hydrogen bond rigidified backbones of aromatic oligoamides are temporarily interrupted by replacing the amide hydrogens with the acid-labile 2,4-dimethoxybenzyl (DMB) group, which allows the efficient preparation of long folding oligomers that, upon removal of the DMB groups, fold into multiturn helices. [structure: see text]

Entities:  

Year:  2006        PMID: 17048857     DOI: 10.1021/ol062103d

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

1.  Large-scale and chromatography-free synthesis of an octameric quinoline-based aromatic amide helical foldamer.

Authors:  Ting Qi; Tiny Deschrijver; Ivan Huc
Journal:  Nat Protoc       Date:  2013-03-14       Impact factor: 13.491

2.  Aromatic foldamers as scaffolds for metal second coordination sphere design.

Authors:  Antoine Meunier; Michael L Singleton; Brice Kauffmann; Thierry Granier; Guillaume Lautrette; Yann Ferrand; Ivan Huc
Journal:  Chem Sci       Date:  2020-10-12       Impact factor: 9.825

  2 in total

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