BACKGROUND AND OBJECTIVES:Bupivacaine is available as a racemic mixture of dextrobupivacaine and levobupivacaine. Many studies show that dextrobupivacaine has a greater inherent central nervous system and cardiovascular toxicity than levobupivacaine. The objective of the present study was to investigate the clinical efficacy and safety of isobaric solution of levobupivacaine compared with hyperbaric solution of racemic bupivacaine in spinal anesthesia. MATERIAL AND METHOD: The authors studied 70 patients undergoingelective transurethral endoscopic surgery who received either 0.5% isobaric levobupivacaine (n = 35) or 0.5% hyperbaric bupivacaine (n = 35) intrathecally, in a randomized, double blind study. RESULTS: The two groups were similar in terms of time to block suitable for surgery, duration of sensory block, time to two segments regression, time to T12 regression, time to onset and offset of motor block, verbal numeric pain scores at the start of the operation and adverse events. CONCLUSION: The present study indicated that 2.5 ml of 0.5% isobaric levobupivacaine and 0.5% hyperbaric of racemic bupivacaine show equally effective potencies for spinal anesthesia, regard to both the onset time and duration of sensory blockade.
RCT Entities:
BACKGROUND AND OBJECTIVES:Bupivacaine is available as a racemic mixture of dextrobupivacaine and levobupivacaine. Many studies show that dextrobupivacaine has a greater inherent central nervous system and cardiovascular toxicity than levobupivacaine. The objective of the present study was to investigate the clinical efficacy and safety of isobaric solution of levobupivacaine compared with hyperbaric solution of racemic bupivacaine in spinal anesthesia. MATERIAL AND METHOD: The authors studied 70 patients undergoing elective transurethral endoscopic surgery who received either 0.5% isobaric levobupivacaine (n = 35) or 0.5% hyperbaric bupivacaine (n = 35) intrathecally, in a randomized, double blind study. RESULTS: The two groups were similar in terms of time to block suitable for surgery, duration of sensory block, time to two segments regression, time to T12 regression, time to onset and offset of motor block, verbal numeric pain scores at the start of the operation and adverse events. CONCLUSION: The present study indicated that 2.5 ml of 0.5% isobaric levobupivacaine and 0.5% hyperbaric of racemic bupivacaine show equally effective potencies for spinal anesthesia, regard to both the onset time and duration of sensory blockade.
Authors: Monica del-Rio-Vellosillo; Jose Javier Garcia-Medina; Antonio Abengochea-Cotaina; Maria Dolores Pinazo-Duran; Manuel Barbera-Alacreu Journal: Biomed Res Int Date: 2014-02-20 Impact factor: 3.411