Literature DB >> 17047684

Orchestrating ontogenesis: variations on a theme by sonic hedgehog.

Philip W Ingham1, Marysia Placzek.   

Abstract

Embryonic development is an emergent process in which increasing complexity is generated by sequential cellular interactions. Recently, it has become clear that such interactions are mediated by just a few families of signalling molecules; but how does this limited repertoire elicit the diversity of form that is characteristic of multicellular organisms? Here we review the various ways in which a member of one such family, the sonic hedgehog (SHH) protein, is deployed during embryonic development. These examples of SHH function provide paradigms for inductive interactions that should help to inform attempts to recapitulate cellular programming and organogenesis in vitro.

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Year:  2006        PMID： 17047684     DOI： 10.1038/nrg1969

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  108 in total

1.  LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome.

Authors:  Yun Li; Barbara Pawlik; Nursel Elcioglu; Mona Aglan; Hülya Kayserili; Gökhan Yigit; Ferda Percin; Frances Goodman; Gudrun Nürnberg; Asim Cenani; Jill Urquhart; Boi-Dinh Chung; Samira Ismail; Khalda Amr; Ayca D Aslanger; Christian Becker; Christian Netzer; Pete Scambler; Wafaa Eyaid; Hanan Hamamy; Jill Clayton-Smith; Raoul Hennekam; Peter Nürnberg; Joachim Herz; Samia A Temtamy; Bernd Wollnik
Journal:  Am J Hum Genet       Date:  2010-04-08       Impact factor: 11.025

Review 2.  Intraretinal projection of retinal ganglion cell axons as a model system for studying axon navigation.

Authors:  Zheng-Zheng Bao
Journal:  Brain Res       Date:  2007-02-02       Impact factor: 3.252

3.  SHH E176/E177-Zn2+ conformation is required for signaling at endogenous sites.

Authors:  Diana S Himmelstein; Ivelisse Cajigas; Chunming Bi; Brian S Clark; Grant Van Der Voort; Jhumku D Kohtz
Journal:  Dev Biol       Date:  2017-03-02       Impact factor: 3.582

4.  Expression profiling identifies novel Hh/Gli-regulated genes in developing zebrafish embryos.

Authors:  Sadie A Bergeron; Luis A Milla; Rosario Villegas; Meng-Chieh Shen; Shawn M Burgess; Miguel L Allende; Rolf O Karlstrom; Verónica Palma
Journal:  Genomics       Date:  2007-12-11       Impact factor: 5.736

5.  A distinct role for secreted fibroblast growth factor-binding proteins in development.

Authors:  Krissa A Gibby; Kevin McDonnell; Marcel O Schmidt; Anton Wellstein
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-11       Impact factor: 11.205

6.  Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.

Authors:  Miao-Hsueh Chen; Christopher W Wilson; Ya-Jun Li; Kelvin King Lo Law; Chi-Sheng Lu; Rhodora Gacayan; Xiaoyun Zhang; Chi-chung Hui; Pao-Tien Chuang
Journal:  Genes Dev       Date:  2009-08-15       Impact factor: 11.361

Review 7.  Aging of signal transduction pathways, and pathology.

Authors:  Morgan E Carlson; Haroldo S Silva; Irina M Conboy
Journal:  Exp Cell Res       Date:  2008-04-07       Impact factor: 3.905

8.  Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium.

Authors:  Ainhoa Callejo; Aphrodite Bilioni; Emanuela Mollica; Nicole Gorfinkiel; Germán Andrés; Carmen Ibáñez; Carlos Torroja; Laura Doglio; Javier Sierra; Isabel Guerrero
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-20       Impact factor: 11.205

Review 9.  Mechanisms and functions of Hedgehog signalling across the metazoa.

Authors:  Philip W Ingham; Yoshiro Nakano; Claudia Seger
Journal:  Nat Rev Genet       Date:  2011-04-19       Impact factor: 53.242

10.  Branching morphogenesis.

Authors:  Arie Horowitz; Michael Simons
Journal:  Circ Res       Date:  2009-01-30       Impact factor: 17.367
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