Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A Drosophila model of Alzheimer's disease.

Literature DB >> 17046662

A Drosophila model of Alzheimer's disease.

Damian C Crowther¹, Richard Page, Dhianjali Chandraratna, David A Lomas.

Abstract

The development of a model of Alzheimer's disease in Drosophila allows us to identify and dissect pathological pathways using the most powerful genetic tools available to biology. By reconstructing essential steps in Alzheimer's pathology, such as amyloid beta peptide and tau overexpression, we can observe clear and rapid phenotypes that are surrogate markers for human disease. The characterization of progressive phenotypes by immunohistochemistry of the brain combined with longevity, climbing, and pseudopupil assays allows the investigator to generate quantitative data. Phenotypes may be modulated by changes in gene expression as part of a genetic screen or by potential therapeutic compounds.

Entities: Chemical

Mesh：

Year: 2006 PMID： 17046662 DOI： 10.1016/S0076-6879(06)12015-7

Source DB: PubMed Journal: Methods Enzymol ISSN： 0076-6879 Impact factor: 1.600

Keyword Cloud
Cited

24 in total

1. A novel inhibitor of amyloid β (Aβ) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease.

Authors: Angela Fortner McKoy; Jermont Chen; Trudi Schupbach; Michael H Hecht
Journal: J Biol Chem Date: 2012-09-19 Impact factor: 5.157

2. Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide.

Authors: Ann-Christin Brorsson; Benedetta Bolognesi; Gian Gaetano Tartaglia; Sarah L Shammas; Giorgio Favrin; Ian Watson; David A Lomas; Fabrizio Chiti; Michele Vendruscolo; Christopher M Dobson; Damian C Crowther; Leila M Luheshi
Journal: Biophys J Date: 2010-04-21 Impact factor: 4.033

3. Ascidians: an invertebrate chordate model to study Alzheimer's disease pathogenesis.

Authors: Michael J Virata; Robert W Zeller
Journal: Dis Model Mech Date: 2010-03-02 Impact factor: 5.758

4. Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids.

Authors: Gennady A Buznikov; Lyudmila A Nikitina; Frederic J Seidler; Theodore A Slotkin; Vladimir V Bezuglov; Ivan Milosević; Lidija Lazarević; Ljubica Rogac; Sabera Ruzdijić; Ljubisa M Rakić
Journal: Neurotoxicol Teratol Date: 2008-05-16 Impact factor: 3.763

5. Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo.

Authors: Leila M Luheshi; Wolfgang Hoyer; Teresa Pereira de Barros; Iris van Dijk Härd; Ann-Christin Brorsson; Bertil Macao; Cecilia Persson; Damian C Crowther; David A Lomas; Stefan Ståhl; Christopher M Dobson; Torleif Härd
Journal: PLoS Biol Date: 2010-03-16 Impact factor: 8.029

A Drosophila model of Alzheimer's disease.

1. A novel inhibitor of amyloid β (Aβ) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease.

2. Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide.

3. Ascidians: an invertebrate chordate model to study Alzheimer's disease pathogenesis.

4. Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids.

5. Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo.

6. Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.

7. Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons.

8. Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease.

9. Modeling Alzheimer's disease: from past to future.

Review 10. Alzheimer's disease: insights from Drosophila melanogaster models.