OBJECTIVE: To study the topography of neurofibrillary tangles (NFT) in cortical and subcortical areas in progressive supranuclear palsy (PSP). METHODS: Pattern analysis was carried out on tau-positive NFT in eight PSP cases. RESULTS: Of the areas studied, NFT were randomly distributed in 68%, regularly distributed in 3%, and clustered in 29%. A regular distribution of clusters was more frequent in cortical than subcortical areas. CONCLUSION: NFT topography in subcortical areas was similar to inclusions in the synucleinopathy multiple system atrophy (MSA) but in cortical areas was comparable to other tauopathies.
OBJECTIVE: To study the topography of neurofibrillary tangles (NFT) in cortical and subcortical areas in progressive supranuclear palsy (PSP). METHODS: Pattern analysis was carried out on tau-positive NFT in eight PSP cases. RESULTS: Of the areas studied, NFT were randomly distributed in 68%, regularly distributed in 3%, and clustered in 29%. A regular distribution of clusters was more frequent in cortical than subcortical areas. CONCLUSION: NFT topography in subcortical areas was similar to inclusions in the synucleinopathy multiple system atrophy (MSA) but in cortical areas was comparable to other tauopathies.
Authors: Richard A Armstrong; Marla Gearing; Eileen H Bigio; Felix F Cruz-Sanchez; Charles Duyckaerts; Ian R A Mackenzie; Robert H Perry; Kari Skullerud; Hideaki Yokoo; Nigel J Cairns Journal: J Neural Transm (Vienna) Date: 2011-07-27 Impact factor: 3.575