Literature DB >> 17045243

Human thioesterase superfamily member 2 (hTHEM2) is co-localized with beta-tubulin onto the microtubule.

Zhongjun Cheng1, Shilai Bao, Xiaoyue Shan, Hang Xu, Weimin Gong.   

Abstract

Human thioesterase superfamily member 2 (hTHEM2) belongs to the hotdog-fold enzyme superfamily but its biological function remains unknown. Tissue specific expression in mouse showed that the encoding gene is highly expressed in the kidney, and moderately expressed in the liver, brain, large intestine, and small intestine. Small interference RNA silencing in cell line HCT116 shows that the hthem2 gene is essential for the cell sustained proliferation. Immunostaining and GFP-Tag experiments show that hTHEM2 is co-localized with microtubules.

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Year:  2006        PMID： 17045243     DOI： 10.1016/j.bbrc.2006.09.105

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

1.  Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates hepatic lipid and glucose metabolism.

Authors:  Hye Won Kang; Michele W Niepel; Shuxin Han; Yuki Kawano; David E Cohen
Journal:  FASEB J       Date:  2012-02-17       Impact factor: 5.191

2.  Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice.

Authors:  Hye Won Kang; Cafer Ozdemir; Yuki Kawano; Katherine B LeClair; Cecile Vernochet; C Ronald Kahn; Susan J Hagen; David E Cohen
Journal:  J Biol Chem       Date:  2013-09-26       Impact factor: 5.157

Review 3.  Deactivating Fatty Acids: Acyl-CoA Thioesterase-Mediated Control of Lipid Metabolism.

Authors:  Veronika Tillander; Stefan E H Alexson; David E Cohen
Journal:  Trends Endocrinol Metab       Date:  2017-04-03       Impact factor: 12.015

4.  The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis.

Authors:  Jian Cao; Hang Xu; Hong Zhao; Weimin Gong; Debra Dunaway-Mariano
Journal:  Biochemistry       Date:  2009-02-17       Impact factor: 3.162

5.  Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs.

Authors:  Jie Wei; Hye Won Kang; David E Cohen
Journal:  Biochem J       Date:  2009-06-26       Impact factor: 3.857

6.  In-depth proteome analysis of Arabidopsis leaf peroxisomes combined with in vivo subcellular targeting verification indicates novel metabolic and regulatory functions of peroxisomes.

Authors:  Sigrun Reumann; Sheng Quan; Kyaw Aung; Pingfang Yang; Kalpana Manandhar-Shrestha; Danielle Holbrook; Nicole Linka; Robert Switzenberg; Curtis G Wilkerson; Andreas P M Weber; Laura J Olsen; Jianping Hu
Journal:  Plant Physiol       Date:  2009-03-27       Impact factor: 8.340

7.  Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization.

Authors:  Yuki Kawano; Baran A Ersoy; Yingxia Li; Shin Nishiumi; Masaru Yoshida; David E Cohen
Journal:  Mol Cell Biol       Date:  2014-04-14       Impact factor: 4.272

8.  Molecular cloning, expression, purification and crystallographic analysis of zebrafish THEM2.

Authors:  Han Li; Feng Gao; Shanshan Yu; Minze Jia; Weimin Gong
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-11-14

9.  Evolutionary divergence and functions of the human acyl-CoA thioesterase gene ( ACOT ) family.

Authors:  Chad Brocker; Christopher Carpenter; Daniel W Nebert; Vasilis Vasiliou
Journal:  Hum Genomics       Date:  2010-08       Impact factor: 4.639

10.  New players on the metabolic stage: How do you like Them Acots?

Authors:  David E Cohen
Journal:  Adipocyte       Date:  2013-01-01       Impact factor: 4.534
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