Literature DB >> 1704314

The rat alpha 2-C4 adrenergic receptor gene encodes a novel pharmacological subtype.

M M Voigt1, S K McCune, R Y Kanterman, C C Felder.   

Abstract

A rat gene and brain cDNA (pA2d) encoding the homologue of the human alpha-C4 adrenergic receptor subtype were isolated and characterized. RNA blots indicate that this gene is expressed in brain, heart and kidney but not in lung, liver or pancreas. Yohimbine, WB-4101 and prasozin all exhibited high affinity for this receptor in binding studies. Clonidine was more potent and efficacious than norepinephrine in inhibiting forskolin-stimulated cAMP production in CHO cells expressing pA2d. Together, these data suggest that the alpha 2-C4 gene product defines a previously undescribed pharmacological subtype of alpha 2-adrenergic receptor.

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Year:  1991        PMID： 1704314     DOI： 10.1016/0014-5793(91)80080-m

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  Regional brain distribution and tissue ontogenic expression of a family of alpha-adrenergic receptor mRNAs in the rat.

Authors:  S K McCune; M M Voigt
Journal:  J Mol Neurosci       Date:  1991       Impact factor: 3.444

2.  A transduction pathway associated with receptors coupled to the inhibitory guanine nucleotide binding protein Gi that amplifies ATP-mediated arachidonic acid release.

Authors:  C C Felder; H L Williams; J Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

3.  Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene.

Authors:  S Schaak; J C Devedjian; C Cayla; Y Sender; H Paris
Journal:  Biochem J       Date:  1997-12-01       Impact factor: 3.857

4.  Delineation of three pharmacological subtypes of alpha 2-adrenoceptor in the rat kidney.

Authors:  S Uhlén; J E Wikberg
Journal:  Br J Pharmacol       Date:  1991-11       Impact factor: 8.739

5.  The evolutionary divergence of neurotransmitter receptors and second-messenger pathways.

Authors:  K J Fryxell
Journal:  J Mol Evol       Date:  1995-07       Impact factor: 2.395

6.  Ontogenic expression of two alpha-1 adrenergic receptor subtypes in the rat brain.

Authors:  S K McCune; J M Hill
Journal:  J Mol Neurosci       Date:  1995       Impact factor: 3.444

7.  Agonist trafficking of G(i/o)-mediated alpha(2A)-adrenoceptor responses in HEL 92.1.7 cells.

Authors:  J P Kukkonen; C C Jansson; K E Akerman
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739

8.  [3H]-MK 912 binding delineates two alpha 2-adrenoceptor subtypes in rat CNS one of which is identical with the cloned pA2d alpha 2-adrenoceptor.

Authors:  S Uhlén; Y Xia; V Chhajlani; C C Felder; J E Wikberg
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

9.  The alpha 2-adrenoceptors of the human retinoblastoma cell line (Y79) may represent an additional example of the alpha 2C-adrenoceptor.

Authors:  M M Gleason; J P Hieble
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739

10.  [3H]-RS-15385-197, a selective and high affinity radioligand for alpha 2-adrenoceptors: implications for receptor classification.

Authors:  A C MacKinnon; A T Kilpatrick; B A Kenny; M Spedding; C M Brown
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739
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