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Literature DB >> 1704312

Molecular cloning and sequence analysis of the cDNA encoding the human acrosin-trypsin inhibitor (HUSI-II).

Abstract

A complete cDNA clone encoding the human acrosin-trypsin inhibitor HUSI-II has been isolated from a cDNA library of human testis and completely sequenced. The cDNA of 594 bp contained an open reading frame of 252 base pairs. The deduced amino acid sequence comprised the complete amino acid sequence of HUSI-II and a putative signal peptide. Northern blotting analysis revealed that HUSI-II is synthesized in testis, epididymis and seminal vesicle, but not in the prostate gland.

Entities: Disease Gene Species

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Year: 1991 PMID： 1704312 DOI： 10.1016/0014-5793(91)80099-o

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

9 in total

1. A male reproduction-related Kazal-type peptidase inhibitor gene in the prawn, Macrobrachium rosenbergii: molecular characterization and expression patterns.

Authors: Jun-Xia Cao; Jie-Qiong Dai; Zhong-Min Dai; Guo-Li Yin; Wei-Jun Yang
Journal: Mar Biotechnol (NY) Date: 2006-09-15 Impact factor: 3.619

2. Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility.

Authors: Li Ma; Heguo Yu; Zimei Ni; Shuanggang Hu; Wubin Ma; Chen Chu; Qiang Liu; Yonglian Zhang
Journal: J Biol Chem Date: 2013-02-19 Impact factor: 5.157

3. Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes.

Authors: Boyeon Lee; Inju Park; Sora Jin; Heejin Choi; Jun Tae Kwon; Jihye Kim; Juri Jeong; Byung-Nam Cho; Edward M Eddy; Chunghee Cho
Journal: J Biol Chem Date: 2011-06-24 Impact factor: 5.157

Molecular cloning and sequence analysis of the cDNA encoding the human acrosin-trypsin inhibitor (HUSI-II).

1. A male reproduction-related Kazal-type peptidase inhibitor gene in the prawn, Macrobrachium rosenbergii: molecular characterization and expression patterns.

2. Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility.

3. Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes.

4. SPINK2 is a prognostic biomarker related to immune infiltration in acute myeloid leukemia.

5. Comparative expression profiling of testis-enriched genes regulated during the development of spermatogonial cells.

6. The seminal acrosin-inhibitor ClTI1/SPINK2 is a fertility-associated marker in the chicken.

Review 7. SPINKs in Tumors: Potential Therapeutic Targets.

Review 8. Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.

9. Protease-nexin I as an androgen-dependent secretory product of the murine seminal vesicle.