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Literature DB >> 17040621

Induction of apoptosis in lymphoid and myeloid leukemia.

Abstract

Defects in the core machinery of the apoptosis pathway contribute to chemoresistance and poor outcomes in patients with acute leukemia. To overcome these defects, novel molecules that target key proteins in the apoptosis pathway are being developed. This review highlights compounds that target the mitochondrial, death receptor, and convergence pathways of caspase activation that are being developed for the treatment of acute leukemia.

Entities: Disease Species

Mesh：

Substances：

Year: 2006 PMID： 17040621 DOI： 10.1007/s11912-006-0071-z

Source DB: PubMed Journal: Curr Oncol Rep ISSN： 1523-3790 Impact factor: 5.075

67 in total

1. NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP.

Authors: C Sun; M Cai; A H Gunasekera; R P Meadows; H Wang; J Chen; H Zhang; W Wu; N Xu; S C Ng; S W Fesik
Journal: Nature Date: 1999-10-21 Impact factor: 49.962

Review 2. Bcl-2 and apoptosis in chronic lymphocytic leukemia.

Authors: Aaron D Schimmer; Irene Munk-Pedersen; Mark D Minden; John C Reed
Journal: Curr Treat Options Oncol Date: 2003-06

3. Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.

Authors: Shinichi Kitada; Marilisa Leone; Sina Sareth; Dayong Zhai; John C Reed; Maurizio Pellecchia
Journal: J Med Chem Date: 2003-09-25 Impact factor: 7.446

4. Dissecting Fas signaling with an altered-specificity death-domain mutant: requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation.

Authors: H Y Chang; X Yang; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1999-02-16 Impact factor: 11.205

5. Granzyme release and caspase activation in activated human T-lymphocytes.

Authors: J M Zapata; R Takahashi; G S Salvesen; J C Reed
Journal: J Biol Chem Date: 1998-03-20 Impact factor: 5.157

6. XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs.

Authors: Fiona L Scott; Jean-Bernard Denault; Stefan J Riedl; Hwain Shin; Martin Renatus; Guy S Salvesen
Journal: EMBO J Date: 2005-01-13 Impact factor: 11.598

7. Rational design of shepherdin, a novel anticancer agent.

Authors: Janet Plescia; Whitney Salz; Fang Xia; Marzia Pennati; Nadia Zaffaroni; Maria Grazia Daidone; Massimiliano Meli; Takehiko Dohi; Paola Fortugno; Yulia Nefedova; Dmitry I Gabrilovich; Giorgio Colombo; Dario C Altieri
Journal: Cancer Cell Date: 2005-05 Impact factor: 31.743

Review 8. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice.

Authors: Aaron D Schimmer
Journal: Cancer Res Date: 2004-10-15 Impact factor: 12.701

9. Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer.

Authors: Shui Ping Tu; Xiao Hua Jiang; Marie C M Lin; Jian Tao Cui; Yi Yang; Ching Tung Lum; Bing Zou; Yan Bo Zhu; Shi Hu Jiang; Wai Man Wong; Annie On-On Chan; Man Fung Yuen; Shiu Kum Lam; Hsiang Fu Kung; Benjamin Chun-Yu Wong
Journal: Cancer Res Date: 2003-11-15 Impact factor: 12.701

10. Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

Authors: Haiying Sun; Zaneta Nikolovska-Coleska; Chao-Yie Yang; Liang Xu; York Tomita; Krzysztof Krajewski; Peter P Roller; Shaomeng Wang
Journal: J Med Chem Date: 2004-08-12 Impact factor: 7.446

1 in total

1. Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia.

Authors: Ina Radtke; Charles G Mullighan; Masami Ishii; Xiaoping Su; Jinjun Cheng; Jing Ma; Ramapriya Ganti; Zhongling Cai; Salil Goorha; Stanley B Pounds; Xueyuan Cao; Caroline Obert; Jianling Armstrong; Jinghui Zhang; Guangchun Song; Raul C Ribeiro; Jeffrey E Rubnitz; Susana C Raimondi; Sheila A Shurtleff; James R Downing
Journal: Proc Natl Acad Sci U S A Date: 2009-07-27 Impact factor: 11.205

1 in total