Literature DB >> 1703988

Equine monoclonal antibodies recognize common epitopes on variants of equine infectious anaemia virus.

L E Perryman1, K I O'Rourke, P H Mason, T C McGuire.   

Abstract

Equine-murine xenohybridoma cells were produced using SP2/0 murine myeloma cells and splenic lymph node cells obtained from horses infected with 10(6) TCID50 of single cloned variants of equine infectious anaemia virus (EIAV). The xenohybridomas secreted equine IgG monoclonal antibodies reactive with EIAV in enzyme immunoassays employing purified virus. Seven antibodies were studied in detail. They bound to viral glycoproteins (gp90 or gp45) in radioimmunoprecipitation assays, and reacted with homologous EIAV as well as five other cloned variants of EIAV. When evaluated against a single cloned variant of EIAV (EIAV-WSU5), two antibodies bound to different epitopes on gp90. The five remaining antibodies reacted with the same or overlapping epitopes on gp45. None of the antibodies exhibited viral neutralizing activity.

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Year:  1990        PMID： 1703988      PMCID： PMC1384884     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  19 in total

Review 1.  The lentiviruses: maedi/visna, caprine arthritis-encephalitis, and equine infectious anemia.

Authors:  W P Cheevers; T C McGuire
Journal:  Adv Virus Res       Date:  1988       Impact factor: 9.937

2.  Role of the host immune response in selection of equine infectious anemia virus variants.

Authors:  S Carpenter; L H Evans; M Sevoian; B Chesebro
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

3.  Viral-induced hemolysis in equine infectious anemia.

Authors:  T C McGuire; J B Henson; S E Quist
Journal:  Am J Vet Res       Date:  1969-12       Impact factor: 1.156

4.  Antigenic variation during persistent infection by equine infectious anemia virus, a retrovirus.

Authors:  R C Montelaro; B Parekh; A Orrego; C J Issel
Journal:  J Biol Chem       Date:  1984-08-25       Impact factor: 5.157

5.  Antiviral, anti-glycoprotein and neutralizing antibodies in foals with equine infectious anaemia virus.

Authors:  K O'Rourke; L E Perryman; T C McGuire
Journal:  J Gen Virol       Date:  1988-03       Impact factor: 3.891

Review 6.  Equine infectious anemia virus: immunopathogenesis and persistence.

Authors:  W P Cheevers; T C McGuire
Journal:  Rev Infect Dis       Date:  1985 Jan-Feb

7.  Cross-neutralizing and subclass characteristics of antibody from horses with equine infectious anemia virus.

Authors:  K I O'Rourke; L E Perryman; T C McGuire
Journal:  Vet Immunol Immunopathol       Date:  1989-11-30       Impact factor: 2.046

8.  Defective thymocyte maturation in horses with severe combined immunodeficiency.

Authors:  C R Wyatt; N S Magnuson; L E Perryman
Journal:  J Immunol       Date:  1987-12-15       Impact factor: 5.422

9.  Antigenic mapping of the envelope proteins of equine infectious anemia virus: identification of a neutralization domain and a conserved region on glycoprotein 90.

Authors:  K A Hussain; C J Issel; K L Schnorr; P M Rwambo; M West; R C Montelaro
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

10.  Immune responses are required to terminate viremia in equine infectious anemia lentivirus infection.

Authors:  L E Perryman; K I O'Rourke; T C McGuire
Journal:  J Virol       Date:  1988-08       Impact factor: 5.103
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  3 in total

1.  Gag protein epitopes recognized by CD4(+) T-helper lymphocytes from equine infectious anemia virus-infected carrier horses.

Authors:  S M Lonning; W Zhang; T C McGuire
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

2.  Detection and induction of equine infectious anemia virus-specific cytotoxic T-lymphocyte responses by use of recombinant retroviral vectors.

Authors:  S M Lonning; W Zhang; S R Leib; T C McGuire
Journal:  J Virol       Date:  1999-04       Impact factor: 5.103

3.  Major histocompatibility complex-restricted CD8+ cytotoxic T lymphocytes from horses with equine infectious anemia virus recognize Env and Gag/PR proteins.

Authors:  T C McGuire; D B Tumas; K M Byrne; M T Hines; S R Leib; A L Brassfield; K I O'Rourke; L E Perryman
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103
  3 in total

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