Literature DB >> 1703968

Influence of murine mast cell growth factor (c-kit ligand) on colony formation by mouse marrow hematopoietic progenitor cells.

H E Broxmeyer1, G Hangoc, S Cooper, D Anderson, D Cosman, S D Lyman, D E Williams.   

Abstract

Purified natural and recombinant murine mast cell growth factor (MGF, a c-kit ligand) were evaluated alone and in combination with other cytokines for effects in vitro on colony formation by multipotential (CFU-GEMM), erythroid (BFU-E) and granulocyte-macrophage (CFU-GM) progenitor cells from BDF1 mouse bone marrow. Both preparations stimulated Epo-dependent CFU-GEMM and enhanced Epo-dependent BFU-E colony numbers and size. MGF had some stimulating activity for CFU-GM. When used in combination with plateau concentrations of pokeweed mitogen mouse spleen cell conditioned medium or granulocyte-macrophage colony stimulating factor (CSF), MGF enhanced in greater than additive fashion colony formation by CFU-GM. MGF also enhanced the size of colonies formed, an enhancement greatest for colonies containing granulocytes and macrophages. MGF did not enhance Macrophage-CSF stimulated colony numbers or size. MGF seems to be an early acting cytokine with preferential effects on the growth of more immature hematopoietic progenitor cells.

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Year:  1991        PMID： 1703968

Source DB:  PubMed          Journal:  Exp Hematol        ISSN： 0301-472X            Impact factor:   3.084


  12 in total

1.  CD1d expression on and regulation of murine hematopoietic stem and progenitor cells.

Authors:  Hal E Broxmeyer; Kent Christopherson; Giao Hangoc; Scott Cooper; Charlie Mantel; Gourapura J Renukaradhya; Randy R Brutkiewicz
Journal:  Blood       Date:  2012-04-25       Impact factor: 22.113

2.  Comparative analysis of the influences of IL-1, IL-3 and GM-CSF on the commitment of granulocyte-macrophage progenitors in vitro.

Authors:  J Maciejewski; H Weber; K Neuhaus; M Wächter; E Elstner; F R Seiler; H D Volk
Journal:  Ann Hematol       Date:  1991-11       Impact factor: 3.673

3.  Stem cell factor induces proliferation and differentiation of highly enriched murine hematopoietic cells.

Authors:  G Migliaccio; A R Migliaccio; J Valinsky; K Langley; K Zsebo; J W Visser; J W Adamson
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

4.  Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc epsilonRI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells.

Authors:  R Pawankar; M Okuda; H Yssel; K Okumura; C Ra
Journal:  J Clin Invest       Date:  1997-04-01       Impact factor: 14.808

5.  The generation of colony-forming cells (CFC) and the expansion of hematopoiesis in cultures of human cord blood cells is dependent on the presence of stem cell factor (SCF).

Authors:  A R Migliaccio; G Migliaccio; B Durand; G C Mancini; J W Adamson
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

6.  A GM-colony-stimulating factor (CSF) activated ribonuclease system transregulates M-CSF receptor expression in the murine FDC-P1/MAC myeloid cell line.

Authors:  B C Gliniak; L S Park; L R Rohrschneider
Journal:  Mol Biol Cell       Date:  1992-05       Impact factor: 4.138

7.  Spontaneous dissociation-association of monomers of the human-stem-cell-factor dimer.

Authors:  H S Lu; W C Chang; E A Mendiaz; M B Mann; K E Langley; Y R Hsu
Journal:  Biochem J       Date:  1995-01-15       Impact factor: 3.857

8.  Expression of the LIM-homeobox gene LH2 generates immortalized steel factor-dependent multipotent hematopoietic precursors.

Authors:  P Pinto do O; A Kolterud; L Carlsson
Journal:  EMBO J       Date:  1998-10-01       Impact factor: 11.598

9.  Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells.

Authors:  W S Alexander; S D Lyman; E F Wagner
Journal:  EMBO J       Date:  1991-12       Impact factor: 11.598

10.  CD45 cell surface antigens are linked to stimulation of early human myeloid progenitor cells by interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), a GM-CSF/IL-3 fusion protein, and mast cell growth factor (a c-kit ligand).

Authors:  H E Broxmeyer; L Lu; G Hangoc; S Cooper; P C Hendrie; J A Ledbetter; M Xiao; D E Williams; F W Shen
Journal:  J Exp Med       Date:  1991-08-01       Impact factor: 14.307
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