Literature DB >> 17038803

Distribution of DJ-1, Parkinson's disease-related protein PARK7, and its alteration in 6-hydroxydopamine-treated hemiparkinsonian rat brain.

Takashi Yanagida1, Kazuyuki Takata, Masatoshi Inden, Yoshihisa Kitamura, Takashi Taniguchi, Kanji Yoshimoto, Takahiro Taira, Hiroyoshi Ariga.   

Abstract

DJ-1 has multiple functions and its dysfunction may be linked to the onset of familial Parkinson's disease PARK7. However, the function and distribution of DJ-1 is unclear. In this study, we determined DJ-1 distribution and change after intranigral injection of 6-hydroxydopamine (6-OHDA). Although distribution of DJ-1 immunoreactivity was not changed in cerebral cortex and striatum, 6-OHDA caused increase of DJ-1 in the particulate fraction and decrease in the cytosolic fraction in substantia nigra. At that time, DJ-1 shifted to acid forms. These results suggest that distributional changes, translocation, and acidic shift of DJ-1 may be compensatory responses to protect against 6-OHDA-induced oxidative stress.

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Year:  2006        PMID： 17038803     DOI： 10.1254/jphs.sc0060098

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  6 in total

1.  DJ-1 mRNA anatomical localization and cell type identification in the mouse brain.

Authors:  Zhiguo Xie; Xiaoxi Zhuang; Linan Chen
Journal:  Neurosci Lett       Date:  2009-09-17       Impact factor: 3.046

2.  Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury.

Authors:  Li Peng; Yipeng Zhao; Yixin Li; Yang Zhou; Linyu Li; Shipeng Lei; Shanshan Yu; Yong Zhao
Journal:  J Mol Med (Berl)       Date:  2018-11-30       Impact factor: 4.599

3.  Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury.

Authors:  Takashi Yanagida; Jun Tsushima; Yoshihisa Kitamura; Daijiro Yanagisawa; Kazuyuki Takata; Tomonori Shibaike; Atsuko Yamamoto; Takashi Taniguchi; Hiroyuki Yasui; Takahiro Taira; Shigehiro Morikawa; Toshihiro Inubushi; Ikuo Tooyama; Hiroyoshi Ariga
Journal:  Oxid Med Cell Longev       Date:  2009 Jan-Mar       Impact factor: 6.543

4.  Oxidative neurodegeneration is prevented by UCP0045037, an allosteric modulator for the reduced form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7.

Authors:  Koichiro Yamane; Yoshihisa Kitamura; Takashi Yanagida; Kazuyuki Takata; Daijiro Yanagisawa; Takashi Taniguchi; Takahiro Taira; Hiroyoshi Ariga
Journal:  Int J Mol Sci       Date:  2009-11-05       Impact factor: 6.208

Review 5.  Neuroprotective function of DJ-1 in Parkinson's disease.

Authors:  Hiroyoshi Ariga; Kazuko Takahashi-Niki; Izumi Kato; Hiroshi Maita; Takeshi Niki; Sanae M M Iguchi-Ariga
Journal:  Oxid Med Cell Longev       Date:  2013-05-16       Impact factor: 6.543

Review 6.  Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology.

Authors:  James N Tsoporis; Ioannis-Alexandros Drosatos; Sahil Gupta; Hajera Amatullah; Shehla Izhar; Claudia C Dos Santos; Vasileos Salpeas; Angelos G Rigopoulos; Ioannis K Toumpoulis; Andreas S Triantafyllis; Eleftharios Sakadakis; Nikolaos Kavantzas; John C Marshall; Ioannis K Rizos; Thomas G Parker
Journal:  Molecules       Date:  2021-06-22       Impact factor: 4.411
  6 in total

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