Literature DB >> 17038706

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces Leishmania major burdens in C57BL/6 mice.

Owen J Bowers1, Kirsa B Sommersted, Ryan T Sowell, Gretchen E Boling, William H Hanneman, Richard G Titus, Gregory K Dekrey.   

Abstract

Acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can suppress adaptive immunity. In this study, pre-exposure of Leishmania major-infected mice to TCDD caused a dose-dependent and unexpected decrease in parasite burdens on day 20 after infection. In contrast, TCDD-mediated lymphoid atrophy, suppressed antibody levels, and enhanced interleukin-2 production were observed as expected. These results suggest that TCDD may enhance resistance to L. major in the face of immune suppression.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17038706

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  7 in total

Review 1.  New insights into the aryl hydrocarbon receptor as a modulator of host responses to infection.

Authors:  B Paige Lawrence; Beth A Vorderstrasse
Journal:  Semin Immunopathol       Date:  2013-08-21       Impact factor: 9.623

2.  Pulmonary paracoccidioidomycosis in AhR deficient hosts is severe and associated with defective Treg and Th22 responses.

Authors:  Eliseu Frank de Araújo; Nycolas Willian Preite; Marc Veldhoen; Flávio Vieira Loures; Vera Lúcia Garcia Calich
Journal:  Sci Rep       Date:  2020-07-09       Impact factor: 4.379

3.  Role of Aryl Hydrocarbon Receptor (AhR) in the Regulation of Immunity and Immunopathology During Trypanosoma cruzi Infection.

Authors:  Laura Fernanda Ambrosio; Constanza Insfran; Ximena Volpini; Eva Acosta Rodriguez; Horacio Marcelo Serra; Francisco J Quintana; Laura Cervi; Claudia Cristina Motrán
Journal:  Front Immunol       Date:  2019-03-29       Impact factor: 7.561

4.  TCDD exposure alters fecal IgA concentrations in male and female mice.

Authors:  Christine L Foxx; Madeline R Nagy; Aspen E King; Dreycey Albin; Gregory K DeKrey
Journal:  BMC Pharmacol Toxicol       Date:  2022-04-21       Impact factor: 2.605

5.  2,3,7,8-tetrachlorodibenzo-p-dioxin slows the progression of experimental cutaneous Leishmaniasis in susceptible BALB/c and SCID mice.

Authors:  Gregory K DeKrey; Riane E Teagarden; Jerica L Lenberg; Richard G Titus
Journal:  PLoS One       Date:  2013-10-01       Impact factor: 3.240

6.  The growth and infectivity of Leishmania major is not altered by in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Authors:  Vera Sazhnev; Gregory K DeKrey
Journal:  BMC Res Notes       Date:  2018-09-04

7.  Aryl Hydrocarbon Receptor-Signaling Regulates Early Leishmania major-Induced Cytokine Expression.

Authors:  Niels-Arne Münck; Johannes Roth; Cord Sunderkötter; Jan Ehrchen
Journal:  Front Immunol       Date:  2019-10-15       Impact factor: 7.561
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.