Literature DB >> 17038685

In vitro activity of artemisone compared with artesunate against Plasmodium falciparum.

Michael Ramharter1, Dominik Burkhardt, Johannes Nemeth, Ayola A Adegnika, Peter G Kremsner.   

Abstract

Artemisinins show the potential for neurotoxicity in preclinical studies. Artemisone is a leading candidate of second-generation semi-synthetic artemisinin derivatives for antimalarial therapy devoid of neurotoxicity. Artemisone showed 3-5-fold higher in vitro activity (50% effective concentration (EC50) = 0.14 nmol/L, EC90 = 2.55 nmol/L) than artesunate against fresh Plasmodium falciparum isolates from Gabon and a high-activity correlation indicates a shared drug target.

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Year:  2006        PMID： 17038685

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  11 in total

1.  In vitro activity of antifungal drugs against Plasmodium falciparum field isolates.

Authors:  Peter Pongratz; Florian Kurth; Ghyslain Mombo Ngoma; Arti Basra; Michael Ramharter
Journal:  Wien Klin Wochenschr       Date:  2011-07-07       Impact factor: 1.704

2.  Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum.

Authors:  Nicanor Obaldia; Barbara M Kotecka; Michael D Edstein; Richard K Haynes; Burkhard Fugmann; Dennis E Kyle; Karl H Rieckmann
Journal:  Antimicrob Agents Chemother       Date:  2009-06-08       Impact factor: 5.191

3.  The Artemisinin Derivative Artemisone Is a Potent Inhibitor of Human Cytomegalovirus Replication.

Authors:  E Oiknine-Djian; Y Weisblum; A Panet; H N Wong; R K Haynes; D G Wolf
Journal:  Antimicrob Agents Chemother       Date:  2018-06-26       Impact factor: 5.191

4.  Glucocorticosteroids in nano-sterically stabilized liposomes are efficacious for elimination of the acute symptoms of experimental cerebral malaria.

Authors:  Judith H Waknine-Grinberg; Simcha Even-Chen; Jasmine Avichzer; Keren Turjeman; Annael Bentura-Marciano; Richard K Haynes; Lola Weiss; Nahum Allon; Haim Ovadia; Jacob Golenser; Yechezkel Barenholz
Journal:  PLoS One       Date:  2013-08-26       Impact factor: 3.240

5.  Plasmodium falciparum isolates from southern Ghana exhibit polymorphisms in the SERCA-type PfATPase6 though sensitive to artesunate in vitro.

Authors:  Bethel Kwansa-Bentum; Irene Ayi; Takashi Suzuki; Joseph Otchere; Takashi Kumagai; William K Anyan; Joseph H N Osei; Hiroko Asahi; Michael F Ofori; Nobuaki Akao; Michael D Wilson; Daniel A Boakye; Nobuo Ohta
Journal:  Malar J       Date:  2011-07-11       Impact factor: 2.979

6.  Anticancer properties of distinct antimalarial drug classes.

Authors:  Rob Hooft van Huijsduijnen; R Kiplin Guy; Kelly Chibale; Richard K Haynes; Ingmar Peitz; Gerhard Kelter; Margaret A Phillips; Jonathan L Vennerstrom; Yongyuth Yuthavong; Timothy N C Wells
Journal:  PLoS One       Date:  2013-12-31       Impact factor: 3.240

7.  Treatment of Experimental Cerebral Malaria by Slow Release of Artemisone From Injectable Pasty Formulation.

Authors:  Jacob Golenser; Nadeen Salaymeh; Abd Alroof Higazi; Mohammed Alyan; Mahran Daif; Ron Dzikowski; Abraham J Domb
Journal:  Front Pharmacol       Date:  2020-06-12       Impact factor: 5.810

8.  New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics.

Authors:  Si-Yuan Pan; Shu-Feng Zhou; Si-Hua Gao; Zhi-Ling Yu; Shuo-Feng Zhang; Min-Ke Tang; Jian-Ning Sun; Dik-Lung Ma; Yi-Fan Han; Wang-Fun Fong; Kam-Ming Ko
Journal:  Evid Based Complement Alternat Med       Date:  2013-03-24       Impact factor: 2.629

9.  Effect of mild medical hypothermia on in vitro growth of Plasmodium falciparum and the activity of anti-malarial drugs.

Authors:  Khalid Rehman; Ulrich Sauerzopf; Luzia Veletzky; Felix Lötsch; Mirjam Groger; Michael Ramharter
Journal:  Malar J       Date:  2016-03-15       Impact factor: 2.979

10.  Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities.

Authors:  Yuet Wu; Silvia Parapini; Ian D Williams; Paola Misiano; Ho Ning Wong; Donatella Taramelli; Nicoletta Basilico; Richard K Haynes
Journal:  Molecules       Date:  2018-07-13       Impact factor: 4.411
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