Literature DB >> 17038626

TLRs in the Gut. III. Immune responses to flagellin in Crohn's disease: good, bad, or irrelevant?

Andrew T Gewirtz1.   

Abstract

Recent observations suggest that bacterial flagellin may be a target of the seemingly aberrant innate and adaptive immune responses that are associated with Crohn's disease. This article discusses the evidence that supports a role for flagellin in Crohn's disease and considers the potential roles of these responses in the pathophysiology of this disorder.

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Year:  2006        PMID： 17038626     DOI： 10.1152/ajpgi.00347.2006

Source DB:  PubMed          Journal:  Am J Physiol Gastrointest Liver Physiol        ISSN： 0193-1857            Impact factor:   4.052


  9 in total

Review 1.  Toll like receptor-5: protecting the gut from enteric microbes.

Authors:  Matam Vijay-Kumar; Jesse D Aitken; Andrew T Gewirtz
Journal:  Semin Immunopathol       Date:  2007-12-07       Impact factor: 9.623

Review 2.  Probiotic therapy: immunomodulating approach toward urinary tract infection.

Authors:  Sarika Amdekar; Vinod Singh; Desh Deepak Singh
Journal:  Curr Microbiol       Date:  2011-09-07       Impact factor: 2.188

3.  Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5.

Authors:  Shervin Assassi; John D Reveille; Frank C Arnett; Michael H Weisman; Michael M Ward; Sandeep K Agarwal; Pravitt Gourh; Jiten Bhula; Roozbeh Sharif; Keeran Sampat; Maureen D Mayes; Filemon K Tan
Journal:  J Rheumatol       Date:  2010-10-15       Impact factor: 4.666

4.  Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis-like systemic inflammatory response in mice.

Authors:  Joëlle Rolli; Noureddine Loukili; Sandra Levrand; Nathalie Rosenblatt-Velin; Stéphanie Rignault-Clerc; Bernard Waeber; François Feihl; Pal Pacher; Lucas Liaudet
Journal:  Crit Care       Date:  2010-08-24       Impact factor: 9.097

Review 5.  The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease.

Authors:  Megan E Himmel; Gijs Hardenberg; Ciriaco A Piccirillo; Theodore S Steiner; Megan K Levings
Journal:  Immunology       Date:  2008-10       Impact factor: 7.397

6.  Effect of bacterial flagellin on thiamin uptake by human and mouse pancreatic acinar cells: inhibition mediated at the level of transcription of thiamin transporters 1 and 2.

Authors:  Padmanabhan Srinivasan; Kasin Yadunandam Anandam; Vignesh Ramesh; Erica T Geltz; Hamid M Said
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2019-03-28       Impact factor: 4.871

7.  Understanding diversity of human innate immunity receptors: analysis of surface features of leucine-rich repeat domains in NLRs and TLRs.

Authors:  Andrei Y Istomin; Adam Godzik
Journal:  BMC Immunol       Date:  2009-09-03       Impact factor: 3.615

8.  Stimulation of human CD4⁺ T lymphocytes via TLR3, TLR5 and TLR7/8 up-regulates expression of costimulatory and modulates proliferation.

Authors:  Rita Simone; Antonio Floriani; Daniele Saverino
Journal:  Open Microbiol J       Date:  2009-01-15

9.  Trained immunity or tolerance: opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors.

Authors:  Daniela C Ifrim; Jessica Quintin; Leo A B Joosten; Cor Jacobs; Trees Jansen; Liesbeth Jacobs; Neil A R Gow; David L Williams; Jos W M van der Meer; Mihai G Netea
Journal:  Clin Vaccine Immunol       Date:  2014-02-12
  9 in total

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